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Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis

Author

Listed:
  • Michael Sigal

    (Max Planck Institute for Infection Biology
    Charité University Medicine
    Berlin Institute of Health)

  • Catriona Y. Logan

    (Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Marta Kapalczynska

    (Max Planck Institute for Infection Biology
    Charité University Medicine)

  • Hans-Joachim Mollenkopf

    (Max Planck Institute for Infection Biology, Core Facility Microarray/Genomics)

  • Hilmar Berger

    (Max Planck Institute for Infection Biology)

  • Bertram Wiedenmann

    (Charité University Medicine)

  • Roeland Nusse

    (Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine)

  • Manuel R. Amieva

    (School of Medicine, Stanford University
    Stanford University School of Medicine)

  • Thomas F. Meyer

    (Max Planck Institute for Infection Biology
    Steinbeis Innovation, Center for Systems Biomedicine)

Abstract

Myofibroblast-derived R-spondin 3 orchestrates regeneration of antral stomach epithelium via Wnt signalling in Axin2+ stem cells.

Suggested Citation

  • Michael Sigal & Catriona Y. Logan & Marta Kapalczynska & Hans-Joachim Mollenkopf & Hilmar Berger & Bertram Wiedenmann & Roeland Nusse & Manuel R. Amieva & Thomas F. Meyer, 2017. "Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis," Nature, Nature, vol. 548(7668), pages 451-455, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7668:d:10.1038_nature23642
    DOI: 10.1038/nature23642
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    Cited by:

    1. Elisa Manieri & Guodong Tie & Ermanno Malagola & Davide Seruggia & Shariq Madha & Adrianna Maglieri & Kun Huang & Yuko Fujiwara & Kevin Zhang & Stuart H. Orkin & Timothy C. Wang & Ruiyang He & Neil Mc, 2023. "Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Naveen Kumar & Pon Ganish Prakash & Christian Wentland & Shilpa Mary Kurian & Gaurav Jethva & Volker Brinkmann & Hans-Joachim Mollenkopf & Tobias Krammer & Christophe Toussaint & Antoine-Emmanuel Sali, 2024. "Decoding spatiotemporal transcriptional dynamics and epithelial fibroblast crosstalk during gastroesophageal junction development through single cell analysis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Marta Kapalczynska & Manqiang Lin & Jeroen Maertzdorf & Julian Heuberger & Stefanie Muellerke & Xiangsheng Zuo & Ramon Vidal & Imad Shureiqi & Anne-Sophie Fischer & Sascha Sauer & Hilmar Berger & Evel, 2022. "BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Manqiang Lin & Kimberly Hartl & Julian Heuberger & Giulia Beccaceci & Hilmar Berger & Hao Li & Lichao Liu & Stefanie Müllerke & Thomas Conrad & Felix Heymann & Andrew Woehler & Frank Tacke & Nikolaus , 2023. "Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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