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CDK4/6 inhibition triggers anti-tumour immunity

Author

Listed:
  • Shom Goel

    (Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute)

  • Molly J. DeCristo

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • April C. Watt

    (Dana-Farber Cancer Institute)

  • Haley BrinJones

    (Dana-Farber Cancer Institute)

  • Jaclyn Sceneay

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • Ben B. Li

    (Dana-Farber Cancer Institute)

  • Naveed Khan

    (Dana-Farber Cancer Institute)

  • Jessalyn M. Ubellacker

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • Shaozhen Xie

    (Dana-Farber Cancer Institute)

  • Otto Metzger-Filho

    (Dana-Farber Cancer Institute)

  • Jeremy Hoog

    (Washington University School of Medicine)

  • Matthew J. Ellis

    (Lester and Sue Smith Breast Center, Baylor College of Medicine)

  • Cynthia X. Ma

    (Washington University School of Medicine)

  • Susanne Ramm

    (Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School
    Brigham and Women’s Hospital)

  • Ian E. Krop

    (Dana-Farber Cancer Institute)

  • Eric P. Winer

    (Dana-Farber Cancer Institute)

  • Thomas M. Roberts

    (Dana-Farber Cancer Institute)

  • Hye-Jung Kim

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Sandra S. McAllister

    (Harvard Medical School
    Brigham and Women’s Hospital
    Harvard Stem Cell Institute, Harvard Medical School
    Broad Institute of Harvard and MIT)

  • Jean J. Zhao

    (Dana-Farber Cancer Institute
    Broad Institute of Harvard and MIT
    Harvard Medical School)

Abstract

Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.

Suggested Citation

  • Shom Goel & Molly J. DeCristo & April C. Watt & Haley BrinJones & Jaclyn Sceneay & Ben B. Li & Naveed Khan & Jessalyn M. Ubellacker & Shaozhen Xie & Otto Metzger-Filho & Jeremy Hoog & Matthew J. Ellis, 2017. "CDK4/6 inhibition triggers anti-tumour immunity," Nature, Nature, vol. 548(7668), pages 471-475, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7668:d:10.1038_nature23465
    DOI: 10.1038/nature23465
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    Cited by:

    1. Lingzhi Hong & Muhammad Aminu & Shenduo Li & Xuetao Lu & Milena Petranovic & Maliazurina B. Saad & Pingjun Chen & Kang Qin & Susan Varghese & Waree Rinsurongkawong & Vadeerat Rinsurongkawong & Amy Spe, 2023. "Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Xue Bai & Ze-Qin Guo & Yan-Pei Zhang & Zhen-zhen Fan & Li-Juan Liu & Li Liu & Li-Li Long & Si-Cong Ma & Jian Wang & Yuan Fang & Xin-Ran Tang & Yu-Jie Zeng & Xinghua Pan & De-Hua Wu & Zhong-Yi Dong, 2023. "CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Dae Joong Kim & Swetha Anandh & Jamie L. Null & Piotr Przanowski & Sanchita Bhatnagar & Pankaj Kumar & Sarah E. Shelton & Erin E. Grundy & Katherine B. Chiappinelli & Roger D. Kamm & David A. Barbie &, 2023. "Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Jana Koch & Sebastian J. Schober & Sruthi V. Hindupur & Caroline Schöning & Florian G. Klein & Klaus Mantwill & Maximilian Ehrenfeld & Ulrike Schillinger & Timmy Hohnecker & Pan Qi & Katja Steiger & M, 2022. "Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Jian Ma & Lei Li & Bohan Ma & Tianjie Liu & Zixi Wang & Qi Ye & Yunhua Peng & Bin Wang & Yule Chen & Shan Xu & Ke Wang & Fabin Dang & Xinyang Wang & Zixuan Zeng & Yanlin Jian & Zhihua Ren & Yizeng Fan, 2024. "MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Wei Zhou & Wenxi Wang & Yuxin Liang & Ruibin Jiang & Fensheng Qiu & Xiying Shao & Yang Liu & Le Fang & Maowei Ni & Chenhuan Yu & Yue Zhao & Weijia Huang & Jiong Li & Michael J. Donovan & Lina Wang & J, 2023. "The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Qiwei Wang & Johann S. Bergholz & Liya Ding & Ziying Lin & Sheheryar K. Kabraji & Melissa E. Hughes & Xiadi He & Shaozhen Xie & Tao Jiang & Weihua Wang & Jason J. Zoeller & Hye-Jung Kim & Thomas M. Ro, 2022. "STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    8. Shunli Fu & Lili Chang & Shujun Liu & Tong Gao & Xiao Sang & Zipeng Zhang & Weiwei Mu & Xiaoqing Liu & Shuang Liang & Han Yang & Huizhen Yang & Qingping Ma & Yongjun Liu & Na Zhang, 2023. "Temperature sensitive liposome based cancer nanomedicine enables tumour lymph node immune microenvironment remodelling," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    9. Jingjie Yi & Omid Tavana & Huan Li & Donglai Wang & Richard J. Baer & Wei Gu, 2023. "Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    10. Shizhong Ke & Fabin Dang & Lin Wang & Jia-Yun Chen & Mandar T. Naik & Wenxue Li & Abhishek Thavamani & Nami Kim & Nandita M. Naik & Huaxiu Sui & Wei Tang & Chenxi Qiu & Kazuhiro Koikawa & Felipe Batal, 2024. "Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    11. Lianmei Tan & Tao Yin & Handan Xiang & Liuyang Wang & Poorva Mudgal & Junying Chen & Yi Ding & Guoping Wang & Bryan Jian Wei Lim & Yuqi Huang & De Huang & Yaosi Liang & Peter B. Alexander & Kun Xiang , 2024. "Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    12. Roberta Piras & Emily Y. Ko & Connor Barrett & Marco Simone & Xianzhi Lin & Marina T. Broz & Fernando H. G. Tessaro & Mireia Castillo-Martin & Carlos Cordon-Cardo & Helen S. Goodridge & Dolores Vizio , 2022. "circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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