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Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation

Author

Listed:
  • Masaki Yagi

    (Center for iPS Cell Research and Application (CiRA), Kyoto University)

  • Satoshi Kishigami

    (Faculty of Life and Environmental Sciences, University of Yamanashi)

  • Akito Tanaka

    (Center for iPS Cell Research and Application (CiRA), Kyoto University)

  • Katsunori Semi

    (Center for iPS Cell Research and Application (CiRA), Kyoto University)

  • Eiji Mizutani

    (Faculty of Life and Environmental Sciences, University of Yamanashi
    Advanced Biotechnology Center, University of Yamanashi)

  • Sayaka Wakayama

    (Faculty of Life and Environmental Sciences, University of Yamanashi
    Advanced Biotechnology Center, University of Yamanashi)

  • Teruhiko Wakayama

    (Faculty of Life and Environmental Sciences, University of Yamanashi
    Advanced Biotechnology Center, University of Yamanashi)

  • Takuya Yamamoto

    (Center for iPS Cell Research and Application (CiRA), Kyoto University
    AMED-CREST, AMED 1-7-1 Otemachi)

  • Yasuhiro Yamada

    (Center for iPS Cell Research and Application (CiRA), Kyoto University)

Abstract

Derivation of female mouse embryonic stem cells under certain conditions induces a loss of DNA methylation and erasure of genomic imprints, which are not recovered and that may contribute to observed impaired development.

Suggested Citation

  • Masaki Yagi & Satoshi Kishigami & Akito Tanaka & Katsunori Semi & Eiji Mizutani & Sayaka Wakayama & Teruhiko Wakayama & Takuya Yamamoto & Yasuhiro Yamada, 2017. "Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation," Nature, Nature, vol. 548(7666), pages 224-227, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7666:d:10.1038_nature23286
    DOI: 10.1038/nature23286
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    Cited by:

    1. Andrew Keniry & Natasha Jansz & Linden J. Gearing & Iromi Wanigasuriya & Joseph Chen & Christian M. Nefzger & Peter F. Hickey & Quentin Gouil & Joy Liu & Kelsey A. Breslin & Megan Iminitoff & Tamara B, 2022. "BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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