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Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Author

Listed:
  • Alexander Raven

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • Wei-Yu Lu

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • Tak Yung Man

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • Sofia Ferreira-Gonzalez

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • Eoghan O’Duibhir

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • Benjamin J. Dwyer

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • John P. Thomson

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Richard R. Meehan

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Roman Bogorad

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Victor Koteliansky

    (Functional Genomics and RNAi Therapy CREI, Skolkovo Institute for Science and Technology)

  • Yuri Kotelevtsev

    (Functional Genomics and RNAi Therapy CREI, Skolkovo Institute for Science and Technology)

  • Charles ffrench-Constant

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

  • Luke Boulter

    (MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh)

  • Stuart J. Forbes

    (MRC Centre for Regenerative Medicine, University of Edinburgh)

Abstract

Two independent systems impairing hepatocyte proliferation during liver injury cause physiologically significant levels of functional hepatocyte regeneration from biliary cells.

Suggested Citation

  • Alexander Raven & Wei-Yu Lu & Tak Yung Man & Sofia Ferreira-Gonzalez & Eoghan O’Duibhir & Benjamin J. Dwyer & John P. Thomson & Richard R. Meehan & Roman Bogorad & Victor Koteliansky & Yuri Kotelevtse, 2017. "Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration," Nature, Nature, vol. 547(7663), pages 350-354, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7663:d:10.1038_nature23015
    DOI: 10.1038/nature23015
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    Cited by:

    1. Beth Lucas & Andrea J. White & Fabian Klein & Clara Veiga-Villauriz & Adam Handel & Andrea Bacon & Emilie J. Cosway & Kieran D. James & Sonia M. Parnell & Izumi Ohigashi & Yousuke Takahama & William E, 2023. "Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Anna R. Smith & Fatima Rizvi & Elissa Everton & Anisah Adeagbo & Susan Wu & Ying Tam & Hiromi Muramatsu & Norbert Pardi & Drew Weissman & Valerie Gouon-Evans, 2024. "Transient growth factor expression via mRNA in lipid nanoparticles promotes hepatocyte cell therapy in mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Inmaculada Ruz-Maldonado & John T. Gonzalez & Hanming Zhang & Jonathan Sun & Alicia Bort & Inamul Kabir & Richard G. Kibbey & Yajaira Suárez & Daniel M. Greif & Carlos Fernández-Hernando, 2024. "Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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