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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

Author

Listed:
  • Ugur Sahin

    (Biopharmaceutical New Technologies (BioNTech) Corporation
    TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH
    University Medical Center of the Johannes Gutenberg University)

  • Evelyna Derhovanessian

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Matthias Miller

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Björn-Philipp Kloke

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Petra Simon

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Martin Löwer

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Valesca Bukur

    (Biopharmaceutical New Technologies (BioNTech) Corporation
    TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Arbel D. Tadmor

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Ulrich Luxemburger

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Barbara Schrörs

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Tana Omokoko

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Mathias Vormehr

    (Biopharmaceutical New Technologies (BioNTech) Corporation
    University Medical Center of the Johannes Gutenberg University)

  • Christian Albrecht

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Anna Paruzynski

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Andreas N. Kuhn

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Janina Buck

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Sandra Heesch

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Katharina H. Schreeb

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Felicitas Müller

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Inga Ortseifer

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Isabel Vogler

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Eva Godehardt

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Sebastian Attig

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH
    University Medical Center of the Johannes Gutenberg University)

  • Richard Rae

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Andrea Breitkreuz

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Claudia Tolliver

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Martin Suchan

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Goran Martic

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Alexander Hohberger

    (University Medical Center of the Johannes Gutenberg University)

  • Patrick Sorn

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Jan Diekmann

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Janko Ciesla

    (EUFETS GmbH)

  • Olga Waksmann

    (EUFETS GmbH)

  • Alexandra-Kemmer Brück

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Meike Witt

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Martina Zillgen

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Andree Rothermel

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Barbara Kasemann

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • David Langer

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Stefanie Bolte

    (Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Mustafa Diken

    (Biopharmaceutical New Technologies (BioNTech) Corporation
    TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Sebastian Kreiter

    (Biopharmaceutical New Technologies (BioNTech) Corporation
    TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH)

  • Romina Nemecek

    (Medical University of Vienna)

  • Christoffer Gebhardt

    (German Cancer Research Center (DKFZ)
    University Medical Center Mannheim, Heidelberg University)

  • Stephan Grabbe

    (University Medical Center of the Johannes Gutenberg University)

  • Christoph Höller

    (Medical University of Vienna)

  • Jochen Utikal

    (German Cancer Research Center (DKFZ)
    University Medical Center Mannheim, Heidelberg University)

  • Christoph Huber

    (Biopharmaceutical New Technologies (BioNTech) Corporation
    TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH
    University Medical Center of the Johannes Gutenberg University)

  • Carmen Loquai

    (University Medical Center of the Johannes Gutenberg University)

  • Özlem Türeci

    (CI3 - Cluster for Individualized Immunointervention e.V)

Abstract

The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma.

Suggested Citation

  • Ugur Sahin & Evelyna Derhovanessian & Matthias Miller & Björn-Philipp Kloke & Petra Simon & Martin Löwer & Valesca Bukur & Arbel D. Tadmor & Ulrich Luxemburger & Barbara Schrörs & Tana Omokoko & Mathi, 2017. "Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer," Nature, Nature, vol. 547(7662), pages 222-226, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7662:d:10.1038_nature23003
    DOI: 10.1038/nature23003
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    Citations

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    Cited by:

    1. Celina Tretter & Niklas Andrade Krätzig & Matteo Pecoraro & Sebastian Lange & Philipp Seifert & Clara Frankenberg & Johannes Untch & Gabriela Zuleger & Mathias Wilhelm & Daniel P. Zolg & Florian S. Dr, 2023. "Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Jens Bauer & Natalie Köhler & Yacine Maringer & Philip Bucher & Tatjana Bilich & Melissa Zwick & Severin Dicks & Annika Nelde & Marissa Dubbelaar & Jonas Scheid & Marcel Wacker & Jonas S. Heitmann & S, 2022. "The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Naomi Hoenisch Gravel & Annika Nelde & Jens Bauer & Lena Mühlenbruch & Sarah M. Schroeder & Marian C. Neidert & Jonas Scheid & Steffen Lemke & Marissa L. Dubbelaar & Marcel Wacker & Anna Dengler & Rei, 2023. "TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. John P. Finnigan & Jenna H. Newman & Yury Patskovsky & Larysa Patskovska & Andrew S. Ishizuka & Geoffrey M. Lynn & Robert A. Seder & Michelle Krogsgaard & Nina Bhardwaj, 2024. "Structural basis for self-discrimination by neoantigen-specific TCRs," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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