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An immunogenic personal neoantigen vaccine for patients with melanoma

Author

Listed:
  • Patrick A. Ott

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital
    Harvard Medical School)

  • Zhuting Hu

    (Dana-Farber Cancer Institute)

  • Derin B. Keskin

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Broad Institute of MIT and Harvard)

  • Sachet A. Shukla

    (Dana-Farber Cancer Institute
    Broad Institute of MIT and Harvard)

  • Jing Sun

    (Dana-Farber Cancer Institute)

  • David J. Bozym

    (Dana-Farber Cancer Institute)

  • Wandi Zhang

    (Dana-Farber Cancer Institute)

  • Adrienne Luoma

    (Dana-Farber Cancer Institute)

  • Anita Giobbie-Hurder

    (Dana-Farber Cancer Institute)

  • Lauren Peter

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
    Ragon Institute of MGH, MIT, and Harvard)

  • Christina Chen

    (Dana-Farber Cancer Institute)

  • Oriol Olive

    (Dana-Farber Cancer Institute)

  • Todd A. Carter

    (Broad Institute of MIT and Harvard)

  • Shuqiang Li

    (Broad Institute of MIT and Harvard)

  • David J. Lieb

    (Broad Institute of MIT and Harvard)

  • Thomas Eisenhaure

    (Broad Institute of MIT and Harvard)

  • Evisa Gjini

    (Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute)

  • Jonathan Stevens

    (Brigham and Women’s Hospital)

  • William J. Lane

    (Brigham and Women’s Hospital)

  • Indu Javeri

    (CuriRx, Inc.)

  • Kaliappanadar Nellaiappan

    (CuriRx, Inc.)

  • Andres M. Salazar

    (Oncovir, Inc.)

  • Heather Daley

    (Dana-Farber Cancer Institute)

  • Michael Seaman

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center)

  • Elizabeth I. Buchbinder

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital
    Harvard Medical School)

  • Charles H. Yoon

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • Maegan Harden

    (Broad Institute of MIT and Harvard)

  • Niall Lennon

    (Broad Institute of MIT and Harvard)

  • Stacey Gabriel

    (Broad Institute of MIT and Harvard)

  • Scott J. Rodig

    (Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute
    Brigham and Women’s Hospital)

  • Dan H. Barouch

    (Harvard Medical School
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
    Ragon Institute of MGH, MIT, and Harvard)

  • Jon C. Aster

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • Gad Getz

    (Harvard Medical School
    Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Kai Wucherpfennig

    (Harvard Medical School
    Dana-Farber Cancer Institute)

  • Donna Neuberg

    (Dana-Farber Cancer Institute)

  • Jerome Ritz

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital
    Harvard Medical School)

  • Eric S. Lander

    (Harvard Medical School
    Broad Institute of MIT and Harvard)

  • Edward F. Fritsch

    (Dana-Farber Cancer Institute
    Broad Institute of MIT and Harvard
    Neon Therapeutics, Inc.)

  • Nir Hacohen

    (Harvard Medical School
    Broad Institute of MIT and Harvard
    Center for Cancer Research, Massachusetts General Hospital)

  • Catherine J. Wu

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital
    Harvard Medical School
    Broad Institute of MIT and Harvard)

Abstract

The results of a phase I trial assessing a personal neoantigen multi-peptide vaccine in patients with melanoma, showing feasibility, safety, and immunogenicity.

Suggested Citation

  • Patrick A. Ott & Zhuting Hu & Derin B. Keskin & Sachet A. Shukla & Jing Sun & David J. Bozym & Wandi Zhang & Adrienne Luoma & Anita Giobbie-Hurder & Lauren Peter & Christina Chen & Oriol Olive & Todd , 2017. "An immunogenic personal neoantigen vaccine for patients with melanoma," Nature, Nature, vol. 547(7662), pages 217-221, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7662:d:10.1038_nature22991
    DOI: 10.1038/nature22991
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    Cited by:

    1. Meghana Pagadala & Timothy J. Sears & Victoria H. Wu & Eva Pérez-Guijarro & Hyo Kim & Andrea Castro & James V. Talwar & Cristian Gonzalez-Colin & Steven Cao & Benjamin J. Schmiedel & Shervin Goudarzi , 2023. "Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Hakimeh Ebrahimi-Nik & Marmar Moussa & Ryan P. Englander & Summit Singhaviranon & Justine Michaux & HuiSong Pak & Hiroko Miyadera & William L. Corwin & Grant L. J. Keller & Adam T. Hagymasi & Tatiana , 2021. "Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    3. Jia He & Chaoyu Wang & Xiao Fang & Junyao Li & Xueying Shen & Junxia Zhang & Cheng Peng & Hongjian Li & Sai Li & Jeffrey M. Karp & Rui Kuai, 2024. "Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Luis F. Schachner & Christopher Mullen & Wilson Phung & Joshua D. Hinkle & Michelle Irwin Beardsley & Tracy Bentley & Peter Day & Christina Tsai & Siddharth Sukumaran & Tomasz Baginski & Danielle DiCa, 2024. "Exposing the molecular heterogeneity of glycosylated biotherapeutics," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Naomi Hoenisch Gravel & Annika Nelde & Jens Bauer & Lena Mühlenbruch & Sarah M. Schroeder & Marian C. Neidert & Jonas Scheid & Steffen Lemke & Marissa L. Dubbelaar & Marcel Wacker & Anna Dengler & Rei, 2023. "TOFIMS mass spectrometry-based immunopeptidomics refines tumor antigen identification," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    6. Dinh-Huy Nguyen & Sung-Hwan You & Hien Thi-Thu Ngo & Khuynh Nguyen & Khang Vuong Tran & Tan-Huy Chu & So-young Kim & Sang-Jun Ha & Yeongjin Hong & Jung-Joon Min, 2024. "Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Georges Bedran & Daniel A. Polasky & Yi Hsiao & Fengchao Yu & Felipe Veiga Leprevost & Javier A. Alfaro & Marcin Cieslik & Alexey I. Nesvizhskii, 2023. "Unraveling the glycosylated immunopeptidome with HLA-Glyco," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    8. Ashish Goyal & Jens Bauer & Joschka Hey & Dimitris N. Papageorgiou & Ekaterina Stepanova & Michael Daskalakis & Jonas Scheid & Marissa Dubbelaar & Boris Klimovich & Dominic Schwarz & Melanie Märklin &, 2023. "DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    9. Haodong Xu & Ruifeng Hu & Xianjun Dong & Lan Kuang & Wenchao Zhang & Chao Tu & Zhihong Li & Zhongming Zhao, 2024. "ImmuneApp for HLA-I epitope prediction and immunopeptidome analysis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    10. John P. Finnigan & Jenna H. Newman & Yury Patskovsky & Larysa Patskovska & Andrew S. Ishizuka & Geoffrey M. Lynn & Robert A. Seder & Michelle Krogsgaard & Nina Bhardwaj, 2024. "Structural basis for self-discrimination by neoantigen-specific TCRs," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    11. Jens Bauer & Natalie Köhler & Yacine Maringer & Philip Bucher & Tatjana Bilich & Melissa Zwick & Severin Dicks & Annika Nelde & Marissa Dubbelaar & Jonas Scheid & Marcel Wacker & Jonas S. Heitmann & S, 2022. "The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    12. Laura Y. Zhou & Fei Zou & Wei Sun, 2023. "Prioritizing candidate peptides for cancer vaccines through predicting peptide presentation by HLA‐I proteins," Biometrics, The International Biometric Society, vol. 79(3), pages 2664-2676, September.
    13. Jacopo Chiaro & Gabriella Antignani & Sara Feola & Michaela Feodoroff & Beatriz Martins & Hanne Cojoc & Salvatore Russo & Manlio Fusciello & Firas Hamdan & Valentina Ferrari & Daniele Ciampi & Ilkka I, 2023. "Development of mesothelioma-specific oncolytic immunotherapy enabled by immunopeptidomics of murine and human mesothelioma tumors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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