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Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation

Author

Listed:
  • Yuka Morikawa

    (Cardiomyocyte Renewal Laboratory, Texas Heart Institute)

  • Todd Heallen

    (Cardiomyocyte Renewal Laboratory, Texas Heart Institute)

  • John Leach

    (Baylor College of Medicine)

  • Yang Xiao

    (Cardiomyocyte Renewal Laboratory, Texas Heart Institute)

  • James F. Martin

    (Cardiomyocyte Renewal Laboratory, Texas Heart Institute
    Baylor College of Medicine
    Program in Developmental Biology, Baylor College of Medicine
    Cardiovascular Research Institute, Baylor College of Medicine)

Abstract

After injury in the heart, postnatal mouse hearts deficient in the Hippo pathway show efficient repair, and in the hearts of Mdx mice (a model of Duchenne muscular dystrophy) Hippo deficiency protects against overload-induced heart failure.

Suggested Citation

  • Yuka Morikawa & Todd Heallen & John Leach & Yang Xiao & James F. Martin, 2017. "Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation," Nature, Nature, vol. 547(7662), pages 227-231, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7662:d:10.1038_nature22979
    DOI: 10.1038/nature22979
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    Cited by:

    1. Donghong Zhang & Jinfeng Ning & Tharmarajan Ramprasath & Changjiang Yu & Xiaoxu Zheng & Ping Song & Zhonglin Xie & Ming-Hui Zou, 2022. "Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Pengcheng Yang & Lihang Zhu & Shiya Wang & Jixing Gong & Jonathan Nimal Selvaraj & Lincai Ye & Hanxiao Chen & Yaoyao Zhang & Gongxin Wang & Wanjun Song & Zilong Li & Lin Cai & Hao Zhang & Donghui Zhan, 2024. "Engineered model of heart tissue repair for exploring fibrotic processes and therapeutic interventions," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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