IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v547y2017i7661d10.1038_nature22981.html
   My bibliography  Save this article

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

Author

Listed:
  • Peng Jin

    (University of California)

  • David Bulkley

    (University of California)

  • Yanmeng Guo

    (University of California)

  • Wei Zhang

    (University of California
    Howard Hughes Medical Institute, University of California)

  • Zhenhao Guo

    (University of California)

  • Walter Huynh

    (University of California)

  • Shenping Wu

    (Howard Hughes Medical Institute, University of California)

  • Shan Meltzer

    (University of California)

  • Tong Cheng

    (University of California
    Howard Hughes Medical Institute, University of California)

  • Lily Yeh Jan

    (University of California
    University of California
    Howard Hughes Medical Institute, University of California)

  • Yuh-Nung Jan

    (University of California
    University of California
    Howard Hughes Medical Institute, University of California)

  • Yifan Cheng

    (University of California
    Howard Hughes Medical Institute, University of California)

Abstract

Single-particle electron cryo-microscopy analysis of the mechanotransduction channel NOMPC reveals that it contains a bundle of four helical spring-shaped ankyrin repeat domains that undergo motion, potentially allowing mechanical movement of the cytoskeleton to be coupled to the opening of the channel.

Suggested Citation

  • Peng Jin & David Bulkley & Yanmeng Guo & Wei Zhang & Zhenhao Guo & Walter Huynh & Shenping Wu & Shan Meltzer & Tong Cheng & Lily Yeh Jan & Yuh-Nung Jan & Yifan Cheng, 2017. "Electron cryo-microscopy structure of the mechanotransduction channel NOMPC," Nature, Nature, vol. 547(7661), pages 118-122, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7661:d:10.1038_nature22981
    DOI: 10.1038/nature22981
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature22981
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature22981?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    2. Yuqi Qin & Daqi Yu & Dan Wu & Jiangqing Dong & William Thomas Li & Chang Ye & Kai Chit Cheung & Yingyi Zhang & Yun Xu & YongQiang Wang & Yun Stone Shi & Shangyu Dang, 2023. "Cryo-EM structure of TMEM63C suggests it functions as a monomer," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Zhengyang Kong & Elvis K. Boahen & Dong Jun Kim & Fenglong Li & Joo Sung Kim & Hyukmin Kweon & So Young Kim & Hanbin Choi & Jin Zhu & Wu Ying & Do Hwan Kim, 2024. "Ultrafast underwater self-healing piezo-ionic elastomer via dynamic hydrophobic-hydrolytic domains," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:547:y:2017:i:7661:d:10.1038_nature22981. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.