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Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

Author

Listed:
  • David Olmeda

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Daniela Cerezo-Wallis

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Erica Riveiro-Falkenbach

    (Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre)

  • Paula C. Pennacchi

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Marta Contreras-Alcalde

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Nuria Ibarz

    (Proteomics Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO))

  • Metehan Cifdaloz

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Xavier Catena

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Tonantzin G. Calvo

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Estela Cañón

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Direna Alonso-Curbelo

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO)
    Memorial Sloan Kettering Cancer Centre)

  • Javier Suarez

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Lisa Osterloh

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

  • Osvaldo Graña

    (Bioinformatics Unit, Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO))

  • Francisca Mulero

    (Molecular Imaging Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO))

  • Diego Megías

    (Confocal Microscopy Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO))

  • Marta Cañamero

    (Histopathology Unit, Biotechnology Programme,Spanish National Cancer Research Centre (CNIO)
    Roche Innovation Center Munich)

  • Jorge L. Martínez-Torrecuadrada

    (Crystallography and Protein Engineering Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO))

  • Chandrani Mondal

    (The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)

  • Julie Di Martino

    (The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)

  • David Lora

    (CIBERESP, Instituto i+12, Hospital Universitario 12 de Octubre)

  • Inés Martinez-Corral

    (Transgenic Mice Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO)
    University of Uppsala)

  • J. Javier Bravo-Cordero

    (The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)

  • Javier Muñoz

    (Proteomics Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO))

  • Susana Puig

    (Melanoma Unit, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques d’August Pi i Sunyer)

  • Pablo Ortiz-Romero

    (Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre)

  • José L. Rodriguez-Peralto

    (Medical School, Universidad Complutense, Instituto i+12, Hospital Universitario 12 de Octubre)

  • Sagrario Ortega

    (Transgenic Mice Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO))

  • María S. Soengas

    (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO))

Abstract

Genetically engineered ‘lymphoreporter’ mouse strains are used to track melanoma dissemination in vivo, identifying midkine as a tumour-secreted factor that acts at a distance, preparing pre-metastatic niches and serving as an indicator of poor prognosis in patients.

Suggested Citation

  • David Olmeda & Daniela Cerezo-Wallis & Erica Riveiro-Falkenbach & Paula C. Pennacchi & Marta Contreras-Alcalde & Nuria Ibarz & Metehan Cifdaloz & Xavier Catena & Tonantzin G. Calvo & Estela Cañón & Di, 2017. "Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine," Nature, Nature, vol. 546(7660), pages 676-680, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7660:d:10.1038_nature22977
    DOI: 10.1038/nature22977
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    Cited by:

    1. Yan Tang & David J. Kwiatkowski & Elizabeth P. Henske, 2022. "Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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