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Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

Author

Listed:
  • Shu Zhu

    (Yale University School of Medicine)

  • Siyuan Ding

    (Stanford University School of Medicine
    Palo Alto Veterans Institute of Research, VA Palo Alto Health Care System)

  • Penghua Wang

    (New York Medical College)

  • Zheng Wei

    (Yale University School of Medicine)

  • Wen Pan

    (Yale University School of Medicine)

  • Noah W. Palm

    (Yale University School of Medicine)

  • Yi Yang

    (Yale University School of Medicine)

  • Hua Yu

    (Yale University School of Medicine)

  • Hua-Bing Li

    (Yale University School of Medicine)

  • Geng Wang

    (Yale University School of Medicine)

  • Xuqiu Lei

    (Yale University School of Medicine)

  • Marcel R. de Zoete

    (Yale University School of Medicine)

  • Jun Zhao

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Yunjiang Zheng

    (Yale University School of Medicine)

  • Haiwei Chen

    (Yale University School of Medicine)

  • Yujiao Zhao

    (New York Medical College)

  • Kellie A. Jurado

    (Yale University School of Medicine)

  • Ningguo Feng

    (Stanford University School of Medicine)

  • Liang Shan

    (Yale University School of Medicine)

  • Yuval Kluger

    (Yale University School of Medicine)

  • Jun Lu

    (Yale University School of Medicine)

  • Clara Abraham

    (Yale University School of Medicine)

  • Erol Fikrig

    (Yale University School of Medicine
    Howard Hughes Medical Institute)

  • Harry B. Greenberg

    (Stanford University School of Medicine
    Palo Alto Veterans Institute of Research, VA Palo Alto Health Care System)

  • Richard A. Flavell

    (Yale University School of Medicine
    Howard Hughes Medical Institute)

Abstract

The inflammasome receptor Nlrp9b defends against enteric viruses by interacting with double-stranded viral RNA-bound helicase Dhx9, triggering gasdermin-D-dependent pyroptotic cell death of infected cells and secretion of Il-18.

Suggested Citation

  • Shu Zhu & Siyuan Ding & Penghua Wang & Zheng Wei & Wen Pan & Noah W. Palm & Yi Yang & Hua Yu & Hua-Bing Li & Geng Wang & Xuqiu Lei & Marcel R. de Zoete & Jun Zhao & Yunjiang Zheng & Haiwei Chen & Yuji, 2017. "Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells," Nature, Nature, vol. 546(7660), pages 667-670, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7660:d:10.1038_nature22967
    DOI: 10.1038/nature22967
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    Cited by:

    1. Xingxing Ren & Qiuyuan Liu & Peirong Zhou & Tingyue Zhou & Decai Wang & Qiao Mei & Richard A. Flavell & Zhanju Liu & Mingsong Li & Wen Pan & Shu Zhu, 2024. "DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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