IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v546y2017i7660d10.1038_nature22795.html
   My bibliography  Save this article

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

Author

Listed:
  • Naomi McGovern

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Amanda Shin

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
    Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine)

  • Gillian Low

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Donovan Low

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Kaibo Duan

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Leong Jing Yao

    (Singhealth Translational Immunology and Inflammation Centre (STIIC), 20 College Road, the Academia, Level 8 Discovery Tower)

  • Rasha Msallam

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Ivy Low

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Nurhidaya Binte Shadan

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Hermi R Sumatoh

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Erin Soon

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Josephine Lum

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Esther Mok

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Sandra Hubert

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Peter See

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Edwin Huang Kunxiang

    (KK Women’s and Children’s Hospital)

  • Yie Hou Lee

    (KK Research Centre, KK Women’s and Children’s Hospital
    OBGYN-Academic Clinical Program, Duke-NUS, Duke-NUS Medical School)

  • Baptiste Janela

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Mahesh Choolani

    (Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block
    Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, National University of Singapore)

  • Citra Nurfarah Zaini Mattar

    (Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block
    Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, National University of Singapore)

  • Yiping Fan

    (KK Women’s and Children’s Hospital
    Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, National University of Singapore)

  • Tony Kiat Hon Lim

    (Singapore General Hospital)

  • Dedrick Kok Hong Chan

    (University Surgical Cluster, National University Health System)

  • Ker-Kan Tan

    (University Surgical Cluster, National University Health System
    Yong Loo Lin School of Medicine, National University of Singapore)

  • John Kit Chung Tam

    (Yong Loo Lin School of Medicine, National University of Singapore)

  • Christopher Schuster

    (DIAID, Medical University of Vienna)

  • Adelheid Elbe-Bürger

    (DIAID, Medical University of Vienna)

  • Xiao-nong Wang

    (Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH)

  • Venetia Bigley

    (Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH)

  • Matthew Collin

    (Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH)

  • Muzlifah Haniffa

    (Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH)

  • Andreas Schlitzer

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
    Myeloid Cell Biology, Life and Medical Science Institute, University of Bonn
    Single Cell Genomics and Epigenomics Unit at the German Center for Neurodegenerative Diseases and the University of Bonn)

  • Michael Poidinger

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Salvatore Albani

    (Singhealth Translational Immunology and Inflammation Centre (STIIC), 20 College Road, the Academia, Level 8 Discovery Tower)

  • Anis Larbi

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Evan W Newell

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

  • Jerry Kok Yen Chan

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building
    KK Women’s and Children’s Hospital
    Experimental Fetal Medicine Group, Yong Loo Lin School of Medicine, National University of Singapore
    Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School)

  • Florent Ginhoux

    (Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, Immunos Building)

Abstract

Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.

Suggested Citation

  • Naomi McGovern & Amanda Shin & Gillian Low & Donovan Low & Kaibo Duan & Leong Jing Yao & Rasha Msallam & Ivy Low & Nurhidaya Binte Shadan & Hermi R Sumatoh & Erin Soon & Josephine Lum & Esther Mok & S, 2017. "Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2," Nature, Nature, vol. 546(7660), pages 662-666, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7660:d:10.1038_nature22795
    DOI: 10.1038/nature22795
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature22795
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature22795?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Eldin Jašarević & Elizabeth M. Hill & Patrick J. Kane & Lindsay Rutt & Trevonn Gyles & Lillian Folts & Kylie D. Rock & Christopher D. Howard & Kathleen E. Morrison & Jacques Ravel & Tracy L. Bale, 2021. "The composition of human vaginal microbiota transferred at birth affects offspring health in a mouse model," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:546:y:2017:i:7660:d:10.1038_nature22795. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.