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PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

Author

Listed:
  • Shafi Kuchay

    (New York University School of Medicine
    NYU Perlmutter Cancer Center, New York University School of Medicine
    Howard Hughes Medical Institute, New York University School of Medicine)

  • Carlotta Giorgi

    (New York University School of Medicine
    NYU Perlmutter Cancer Center, New York University School of Medicine
    Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara)

  • Daniele Simoneschi

    (New York University School of Medicine
    NYU Perlmutter Cancer Center, New York University School of Medicine)

  • Julia Pagan

    (New York University School of Medicine
    NYU Perlmutter Cancer Center, New York University School of Medicine
    Howard Hughes Medical Institute, New York University School of Medicine)

  • Sonia Missiroli

    (Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara)

  • Anita Saraf

    (The Stowers Institute for Medical Research)

  • Laurence Florens

    (The Stowers Institute for Medical Research)

  • Michael P. Washburn

    (The Stowers Institute for Medical Research
    The University of Kansas Medical Center)

  • Ana Collazo-Lorduy

    (Department of Pathology at Icahn School of Medicine at Mount Sinai
    Spanish Society of Medical Oncology)

  • Mireia Castillo-Martin

    (Department of Pathology at Icahn School of Medicine at Mount Sinai
    Department of Pathology at Champalimaud Centre for the Unknown)

  • Carlos Cordon-Cardo

    (Department of Pathology at Icahn School of Medicine at Mount Sinai)

  • Said M. Sebti

    (Moffitt Cancer Center, University of South Florida)

  • Paolo Pinton

    (Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara)

  • Michele Pagano

    (New York University School of Medicine
    NYU Perlmutter Cancer Center, New York University School of Medicine
    Howard Hughes Medical Institute, New York University School of Medicine)

Abstract

PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.

Suggested Citation

  • Shafi Kuchay & Carlotta Giorgi & Daniele Simoneschi & Julia Pagan & Sonia Missiroli & Anita Saraf & Laurence Florens & Michael P. Washburn & Ana Collazo-Lorduy & Mireia Castillo-Martin & Carlos Cordon, 2017. "PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth," Nature, Nature, vol. 546(7659), pages 554-558, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7659:d:10.1038_nature22965
    DOI: 10.1038/nature22965
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    Cited by:

    1. Mengmeng Niu & Jing Xu & Yang Liu & Yuhuang Li & Tao He & Liangping Ding & Yajun He & Yong Yi & Fengtian Li & Rongtian Guo & Ya Gao & Rui Li & Luping Li & Mengyuan Fu & Qingyong Hu & Yangkun Luo & Chu, 2021. "FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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