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Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge

Author

Listed:
  • Matthew J. Emmett

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Hee-Woong Lim

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Perelman School of Medicine at the University of Pennsylvania)

  • Jennifer Jager

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Hannah J. Richter

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Marine Adlanmerini

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Lindsey C. Peed

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Erika R. Briggs

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • David J. Steger

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Tao Ma

    (Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
    Institute for Neuroscience and Pharmacology, University of Copenhagen)

  • Carrie A. Sims

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    The Trauma Center at Penn, Perelman School of Medicine at the University of Pennsylvania)

  • Joseph A. Baur

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Perelman School of Medicine at the University of Pennsylvania)

  • Liming Pei

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia
    Perelman School of Medicine at the University of Pennsylvania)

  • Kyoung-Jae Won

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Perelman School of Medicine at the University of Pennsylvania)

  • Patrick Seale

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Perelman School of Medicine at the University of Pennsylvania)

  • Zachary Gerhart-Hines

    (Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen
    Institute for Neuroscience and Pharmacology, University of Copenhagen)

  • Mitchell A. Lazar

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Perelman School of Medicine at the University of Pennsylvania)

Abstract

Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude.

Suggested Citation

  • Matthew J. Emmett & Hee-Woong Lim & Jennifer Jager & Hannah J. Richter & Marine Adlanmerini & Lindsey C. Peed & Erika R. Briggs & David J. Steger & Tao Ma & Carrie A. Sims & Joseph A. Baur & Liming Pe, 2017. "Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge," Nature, Nature, vol. 546(7659), pages 544-548, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7659:d:10.1038_nature22819
    DOI: 10.1038/nature22819
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    Cited by:

    1. Yong Geun Jeon & Hahn Nahmgoong & Jiyoung Oh & Dabin Lee & Dong Wook Kim & Jane Eunsoo Kim & Ye Young Kim & Yul Ji & Ji Seul Han & Sung Min Kim & Jee Hyung Sohn & Won Taek Lee & Sun Won Kim & Jeu Park, 2024. "Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Tongling Huang & Zhaocheng Lu & Zihui Wang & Lixin Cheng & Lu Gao & Jun Gao & Ning Zhang & Chang-An Geng & Xiaoli Zhao & Huaiyu Wang & Chi-Wai Wong & Kelvin W. K. Yeung & Haobo Pan & William Weijia Lu, 2024. "Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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