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Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

Author

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  • Stefano Stella

    (Protein Structure & Function Programme, Macromolecular Crystallography Group, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Pablo Alcón

    (Protein Structure & Function Programme, Macromolecular Crystallography Group, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Guillermo Montoya

    (Protein Structure & Function Programme, Macromolecular Crystallography Group, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

Abstract

The structure of Cpf1, a CRISPR–Cas/RNA-guided nuclease, is presented with a three-stranded RNA–DNA loop after cleavage, providing insight into its working mechanism.

Suggested Citation

  • Stefano Stella & Pablo Alcón & Guillermo Montoya, 2017. "Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage," Nature, Nature, vol. 546(7659), pages 559-563, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7659:d:10.1038_nature22398
    DOI: 10.1038/nature22398
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