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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival

Author

Listed:
  • Haizhen Wang

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Brandon N. Nicolay

    (Massachusetts General Hospital Cancer Center)

  • Joel M. Chick

    (Harvard Medical School)

  • Xueliang Gao

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Yan Geng

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Hong Ren

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Hui Gao

    (Novartis Institutes for Biomedical Research)

  • Guizhi Yang

    (Novartis Institutes for Biomedical Research)

  • Juliet A. Williams

    (Novartis Institutes for Biomedical Research)

  • Jan M. Suski

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Mark A. Keibler

    (Massachusetts Institute of Technology)

  • Ewa Sicinska

    (Dana-Farber Cancer Institute)

  • Ulrike Gerdemann

    (Dana-Farber Cancer Institute)

  • W. Nicholas Haining

    (Dana-Farber Cancer Institute
    Children’s Hospital
    Broad Institute of MIT and Harvard)

  • Thomas M. Roberts

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Kornelia Polyak

    (Dana-Farber Cancer Institute)

  • Steven P. Gygi

    (Harvard Medical School)

  • Nicholas J. Dyson

    (Massachusetts General Hospital Cancer Center)

  • Piotr Sicinski

    (Dana-Farber Cancer Institute
    Harvard Medical School)

Abstract

The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in cells, promoting tumour cell survival.

Suggested Citation

  • Haizhen Wang & Brandon N. Nicolay & Joel M. Chick & Xueliang Gao & Yan Geng & Hong Ren & Hui Gao & Guizhi Yang & Juliet A. Williams & Jan M. Suski & Mark A. Keibler & Ewa Sicinska & Ulrike Gerdemann &, 2017. "The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival," Nature, Nature, vol. 546(7658), pages 426-430, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7658:d:10.1038_nature22797
    DOI: 10.1038/nature22797
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    Cited by:

    1. Wei Zhou & Wenxi Wang & Yuxin Liang & Ruibin Jiang & Fensheng Qiu & Xiying Shao & Yang Liu & Le Fang & Maowei Ni & Chenhuan Yu & Yue Zhao & Weijia Huang & Jiong Li & Michael J. Donovan & Lina Wang & J, 2023. "The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Quanyuan Wan & Leah Tavakoli & Ting-Yu Wang & Andrew J. Tucker & Ruiting Zhou & Qizhi Liu & Shu Feng & Dongwon Choi & Zhiheng He & Michaela U. Gack & Jun Zhao, 2024. "Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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