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Nutrient acquisition strategies of mammalian cells

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  • Wilhelm Palm

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center)

  • Craig B. Thompson

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center)

Abstract

Mammalian cells are surrounded by diverse nutrients, such as glucose, amino acids, various macromolecules and micronutrients, which they can import through transmembrane transporters and endolysosomal pathways. By using different nutrient sources, cells gain metabolic flexibility to survive periods of starvation. Quiescent cells take up sufficient nutrients to sustain homeostasis. However, proliferating cells depend on growth-factor-induced increases in nutrient uptake to support biomass formation. Here, we review cellular nutrient acquisition strategies and their regulation by growth factors and cell-intrinsic nutrient sensors. We also discuss how oncogenes and tumour suppressors promote nutrient uptake and thereby support the survival and growth of cancer cells.

Suggested Citation

  • Wilhelm Palm & Craig B. Thompson, 2017. "Nutrient acquisition strategies of mammalian cells," Nature, Nature, vol. 546(7657), pages 234-242, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7657:d:10.1038_nature22379
    DOI: 10.1038/nature22379
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    Cited by:

    1. Nicole Kiweler & Catherine Delbrouck & Vitaly I. Pozdeev & Laura Neises & Leticia Soriano-Baguet & Kim Eiden & Feng Xian & Mohaned Benzarti & Lara Haase & Eric Koncina & Maryse Schmoetten & Christian , 2022. "Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Soeun Kang & Maciek R. Antoniewicz & Nissim Hay, 2024. "Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Edoardo Ratto & S. Roy Chowdhury & Nora S. Siefert & Martin Schneider & Marten Wittmann & Dominic Helm & Wilhelm Palm, 2022. "Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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