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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

Author

Listed:
  • Alejandra Mendoza

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine)

  • Victoria Fang

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine)

  • Cynthia Chen

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine)

  • Madhavika Serasinghe

    (Icahn School of Medicine at Mount Sinai)

  • Akanksha Verma

    (Institute for Computational Biomedicine, Weill Cornell Medical College)

  • James Muller

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine)

  • V. Sai Chaluvadi

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine)

  • Michael L. Dustin

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine
    Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive)

  • Timothy Hla

    (Vascular Biology Program, Boston Children's Hospital, Harvard Medical School)

  • Olivier Elemento

    (Institute for Computational Biomedicine, Weill Cornell Medical College)

  • Jerry E. Chipuk

    (Icahn School of Medicine at Mount Sinai)

  • Susan R. Schwab

    (Skirball Institute of Biomolecular Medicine, New York University School of Medicine)

Abstract

The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.

Suggested Citation

  • Alejandra Mendoza & Victoria Fang & Cynthia Chen & Madhavika Serasinghe & Akanksha Verma & James Muller & V. Sai Chaluvadi & Michael L. Dustin & Timothy Hla & Olivier Elemento & Jerry E. Chipuk & Susa, 2017. "Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells," Nature, Nature, vol. 546(7656), pages 158-161, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7656:d:10.1038_nature22352
    DOI: 10.1038/nature22352
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