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Blocking FSH induces thermogenic adipose tissue and reduces body fat

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  • Peng Liu

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Yaoting Ji

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai
    School and Hospital of Stomatology, Wuhan University, and Key Laboratory of Oral Biomedicine, Ministry of Education)

  • Tony Yuen

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Elizabeth Rendina-Ruedy

    (Maine Medical Center Research Institute)

  • Victoria E. DeMambro

    (Maine Medical Center Research Institute)

  • Samarth Dhawan

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Wahid Abu-Amer

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Sudeh Izadmehr

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Bin Zhou

    (Columbia University)

  • Andrew C. Shin

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Rauf Latif

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Priyanthan Thangeswaran

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Animesh Gupta

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Jianhua Li

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Valeria Shnayder

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Samuel T. Robinson

    (Columbia University)

  • Yue Eric Yu

    (Columbia University)

  • Xingjian Zhang

    (Columbia University)

  • Feiran Yang

    (Columbia University)

  • Ping Lu

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Yu Zhou

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Ling-Ling Zhu

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Douglas J. Oberlin

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Terry F. Davies

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Michaela R. Reagan

    (Maine Medical Center Research Institute)

  • Aaron Brown

    (Maine Medical Center Research Institute)

  • T. Rajendra Kumar

    (University of Colorado School of Medicine)

  • Solomon Epstein

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Jameel Iqbal

    (Pathology Service, Greater Los Angeles Veterans Affairs Medical Center)

  • Narayan G. Avadhani

    (Deparment of Animal Biology, University of Pennsylvania School of Veterinary Medicine)

  • Maria I. New

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Henrik Molina

    (Proteomics Resource Center, Rockefeller University)

  • Jan B. van Klinken

    (Leiden University Medical Center)

  • Edward X. Guo

    (Columbia University)

  • Christoph Buettner

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Shozeb Haider

    (University College London School of Pharmacy)

  • Zhuan Bian

    (School and Hospital of Stomatology, Wuhan University, and Key Laboratory of Oral Biomedicine, Ministry of Education)

  • Li Sun

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

  • Clifford J. Rosen

    (Maine Medical Center Research Institute)

  • Mone Zaidi

    (and Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai)

Abstract

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.

Suggested Citation

  • Peng Liu & Yaoting Ji & Tony Yuen & Elizabeth Rendina-Ruedy & Victoria E. DeMambro & Samarth Dhawan & Wahid Abu-Amer & Sudeh Izadmehr & Bin Zhou & Andrew C. Shin & Rauf Latif & Priyanthan Thangeswaran, 2017. "Blocking FSH induces thermogenic adipose tissue and reduces body fat," Nature, Nature, vol. 546(7656), pages 107-112, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7656:d:10.1038_nature22342
    DOI: 10.1038/nature22342
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    Cited by:

    1. Sen Qiao & Samer Alasmi & Amanda Wyatt & Philipp Wartenberg & Hongmei Wang & Michael Candlish & Debajyoti Das & Mari Aoki & Ramona Grünewald & Ziyue Zhou & Qinghai Tian & Qiang Yu & Viktoria Götz & An, 2023. "Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Jia Duan & Peiyu Xu & Huibing Zhang & Xiaodong Luan & Jiaqi Yang & Xinheng He & Chunyou Mao & Dan-Dan Shen & Yujie Ji & Xi Cheng & Hualiang Jiang & Yi Jiang & Shuyang Zhang & Yan Zhang & H. Eric Xu, 2023. "Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Yi Cheng & Hong Zhu & Jun Ren & Hai-Yan Wu & Jia-En Yu & Lu-Yang Jin & Hai-Yan Pang & Hai-Tao Pan & Si-Si Luo & Jing Yan & Kai-Xuan Dong & Long-Yun Ye & Cheng-Liang Zhou & Jie-Xue Pan & Zhuo-Xian Meng, 2023. "Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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