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Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

Author

Listed:
  • Ayuna Hattori

    (Franklin College of Arts and Sciences, The University of Georgia
    The University of Georgia Cancer Center, The University of Georgia)

  • Makoto Tsunoda

    (Graduate School of Pharmaceutical Sciences, The University of Tokyo)

  • Takaaki Konuma

    (The Institute of Medical Science, The University of Tokyo)

  • Masayuki Kobayashi

    (The Institute of Medical Science, The University of Tokyo)

  • Tamas Nagy

    (College of Veterinary Medicine, The University of Georgia)

  • John Glushka

    (Complex Carbohydrate Research Center, The University of Georgia)

  • Fariba Tayyari

    (Franklin College of Arts and Sciences, The University of Georgia
    Complex Carbohydrate Research Center, The University of Georgia)

  • Daniel McSkimming

    (Franklin College of Arts and Sciences, The University of Georgia
    Institute of Bioinformatics, The University of Georgia)

  • Natarajan Kannan

    (Franklin College of Arts and Sciences, The University of Georgia
    The University of Georgia Cancer Center, The University of Georgia
    Institute of Bioinformatics, The University of Georgia)

  • Arinobu Tojo

    (The Institute of Medical Science, The University of Tokyo)

  • Arthur S. Edison

    (Franklin College of Arts and Sciences, The University of Georgia
    Complex Carbohydrate Research Center, The University of Georgia
    Institute of Bioinformatics, The University of Georgia
    Franklin College of Arts and Sciences, The University of Georgia)

  • Takahiro Ito

    (Franklin College of Arts and Sciences, The University of Georgia
    The University of Georgia Cancer Center, The University of Georgia)

Abstract

BCAT1, a cytosolic aminotransferase for branched-chain amino acids (BCAAs), is aberrantly activated and functionally required for disease progression in chronic myeloid leukaemia.

Suggested Citation

  • Ayuna Hattori & Makoto Tsunoda & Takaaki Konuma & Masayuki Kobayashi & Tamas Nagy & John Glushka & Fariba Tayyari & Daniel McSkimming & Natarajan Kannan & Arinobu Tojo & Arthur S. Edison & Takahiro It, 2017. "Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia," Nature, Nature, vol. 545(7655), pages 500-504, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7655:d:10.1038_nature22314
    DOI: 10.1038/nature22314
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    Cited by:

    1. Mohammed Ferdous-Ur Rahman & Yue Yang & Bao T. Le & Avik Dutta & Julia Posyniak & Patrick Faughnan & Mohammad A. Sayem & Nadine S. Aguilera & Golam Mohi, 2022. "Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Tea Pemovska & Johannes W. Bigenzahn & Ismet Srndic & Alexander Lercher & Andreas Bergthaler & Adrián César-Razquin & Felix Kartnig & Christoph Kornauth & Peter Valent & Philipp B. Staber & Giulio Sup, 2021. "Metabolic drug survey highlights cancer cell dependencies and vulnerabilities," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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