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TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

Author

Listed:
  • Bin Wang

    (Institute of Surgery Research, Daping Hospital, Third Military Medical University
    Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Zuliang Jie

    (The University of Texas MD Anderson Cancer Center)

  • Donghyun Joo

    (The University of Texas MD Anderson Cancer Center)

  • Alban Ordureau

    (Harvard Medical School)

  • Pengda Liu

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Wenjian Gan

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jianping Guo

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jinfang Zhang

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Brian J. North

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Xiangpeng Dai

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Xuhong Cheng

    (The University of Texas MD Anderson Cancer Center)

  • Xiuwu Bian

    (Institute of Pathology and Southwest Cancer Center and Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Southwest Hospital, Third Military Medical University)

  • Lingqiang Zhang

    (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine)

  • J. Wade Harper

    (Harvard Medical School)

  • Shao-Cong Sun

    (The University of Texas MD Anderson Cancer Center)

  • Wenyi Wei

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

Abstract

Ubiquitination of the GβL subunit, a component of both mTORC1 and mTORC2, acts as a regulatory switching mechanism to balance levels of mTORC1 and mTORC2; the failure of this mechanism in some cancers leads to elevated mTORC2 formation and tumorigenesis.

Suggested Citation

  • Bin Wang & Zuliang Jie & Donghyun Joo & Alban Ordureau & Pengda Liu & Wenjian Gan & Jianping Guo & Jinfang Zhang & Brian J. North & Xiangpeng Dai & Xuhong Cheng & Xiuwu Bian & Lingqiang Zhang & J. Wad, 2017. "TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling," Nature, Nature, vol. 545(7654), pages 365-369, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7654:d:10.1038_nature22344
    DOI: 10.1038/nature22344
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    Cited by:

    1. Wenjun Xiong & Xueliang Gao & Tiantian Zhang & Baishan Jiang & Ming-Ming Hu & Xia Bu & Yang Gao & Lin-Zhou Zhang & Bo-Lin Xiao & Chuan He & Yishuang Sun & Haiou Li & Jie Shi & Xiangling Xiao & Bolin X, 2022. "USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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