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A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

Author

Listed:
  • Tuomas Tammela

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Francisco J. Sanchez-Rivera

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Naniye Malli Cetinbas

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Katherine Wu

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Nikhil S. Joshi

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Katja Helenius

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Yoona Park

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Roxana Azimi

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Natanya R. Kerper

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • R. Alexander Wesselhoeft

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Xin Gu

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Leah Schmidt

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Milton Cornwall-Brady

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Ömer H. Yilmaz

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Wen Xue

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    RNA Therapeutics Institute, Program in Molecular Medicine, Cell and Cancer Biology, University of Massachusetts Medical School)

  • Pekka Katajisto

    (Institute of Biotechnology, University of Helsinki
    Karolinska Institutet)

  • Arjun Bhutkar

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Tyler Jacks

    (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

Abstract

A subset of Kras and p53 mutant cancer cells acts as a Wnt-producing niche for another cancer cell subset, and porcupine inhibition disrupts Wnt secretion in this niche, thereby suppressing proliferative potential and leading to therapeutic benefit.

Suggested Citation

  • Tuomas Tammela & Francisco J. Sanchez-Rivera & Naniye Malli Cetinbas & Katherine Wu & Nikhil S. Joshi & Katja Helenius & Yoona Park & Roxana Azimi & Natanya R. Kerper & R. Alexander Wesselhoeft & Xin , 2017. "A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma," Nature, Nature, vol. 545(7654), pages 355-359, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7654:d:10.1038_nature22334
    DOI: 10.1038/nature22334
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    Cited by:

    1. Zhoufeng Wang & Zhe Li & Kun Zhou & Chengdi Wang & Lili Jiang & Li Zhang & Ying Yang & Wenxin Luo & Wenliang Qiao & Gang Wang & Yinyun Ni & Shuiping Dai & Tingting Guo & Guiyi Ji & Minjie Xu & Yiying , 2021. "Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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