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Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

Author

Listed:
  • Thomas Kammertoens

    (Institute of Immunology, Charité Campus Buch
    Max Delbrück Center for Molecular Medicine)

  • Christian Friese

    (Institute of Immunology, Charité Campus Buch
    Max Delbrück Center for Molecular Medicine)

  • Ainhoa Arina

    (Ludwig Center for Metastasis Research, The University of Chicago)

  • Christian Idel

    (The University of Chicago
    University of Luebeck)

  • Dana Briesemeister

    (Institute of Immunology, Charité Campus Buch
    Max Delbrück Center for Molecular Medicine)

  • Michael Rothe

    (Institute of Immunology, Charité Campus Buch
    Max Delbrück Center for Molecular Medicine)

  • Andranik Ivanov

    (Berlin Institute of Health
    Charité - Universitätsmedizin)

  • Anna Szymborska

    (Max Delbrück Center for Molecular Medicine)

  • Giannino Patone

    (Max Delbrück Center for Molecular Medicine)

  • Severine Kunz

    (Max Delbrück Center for Molecular Medicine)

  • Daniel Sommermeyer

    (Max Delbrück Center for Molecular Medicine)

  • Boris Engels

    (Max Delbrück Center for Molecular Medicine)

  • Matthias Leisegang

    (Institute of Immunology, Charité Campus Buch
    Max Delbrück Center for Molecular Medicine
    Berlin Institute of Health)

  • Ana Textor

    (Institute of Immunology, Charité Campus Buch
    Max Delbrück Center for Molecular Medicine)

  • Hans Joerg Fehling

    (Institute of Immunology, University Clinics Ulm)

  • Marcus Fruttiger

    (Institute of Ophthalmology, University College London)

  • Michael Lohoff

    (Institute for Medical Microbiology, University of Marburg)

  • Andreas Herrmann

    (Beckman Research Institute at the Comprehensive Cancer Center City of Hope, Los Angeles)

  • Hua Yu

    (Beckman Research Institute at the Comprehensive Cancer Center City of Hope, Los Angeles)

  • Ralph Weichselbaum

    (Ludwig Center for Metastasis Research, The University of Chicago)

  • Wolfgang Uckert

    (Max Delbrück Center for Molecular Medicine
    Berlin Institute of Health)

  • Norbert Hübner

    (Max Delbrück Center for Molecular Medicine
    Charité - Universitätsmedizin
    DZHK (German Center for Cardiovascular Research), partner site Berlin)

  • Holger Gerhardt

    (Max Delbrück Center for Molecular Medicine
    Berlin Institute of Health
    DZHK (German Center for Cardiovascular Research), partner site Berlin)

  • Dieter Beule

    (Max Delbrück Center for Molecular Medicine
    Berlin Institute of Health)

  • Hans Schreiber

    (Institute of Immunology, Charité Campus Buch
    The University of Chicago
    Berlin Institute of Health)

  • Thomas Blankenstein

    (Institute of Immunology, Charité Campus Buch
    Max Delbrück Center for Molecular Medicine
    Berlin Institute of Health)

Abstract

Interferon-γ acts on tumour endothelial cells to drive vascular regression, inducing ischaemia that leads to tumour collapse.

Suggested Citation

  • Thomas Kammertoens & Christian Friese & Ainhoa Arina & Christian Idel & Dana Briesemeister & Michael Rothe & Andranik Ivanov & Anna Szymborska & Giannino Patone & Severine Kunz & Daniel Sommermeyer & , 2017. "Tumour ischaemia by interferon-γ resembles physiological blood vessel regression," Nature, Nature, vol. 545(7652), pages 98-102, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7652:d:10.1038_nature22311
    DOI: 10.1038/nature22311
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