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Polyglutamine tracts regulate beclin 1-dependent autophagy

Author

Listed:
  • Avraham Ashkenazi

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • Carla F. Bento

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • Thomas Ricketts

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • Mariella Vicinanza

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • Farah Siddiqi

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • Mariana Pavel

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • Ferdinando Squitieri

    (IRCCS Casa Sollievo della Sofferenza, Huntington and Rare Diseases Unit)

  • Maarten C. Hardenberg

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • Sara Imarisio

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • Fiona M. Menzies

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

  • David C. Rubinsztein

    (Cambridge Institute for Medical Research (CIMR), University of Cambridge)

Abstract

The polyglutamine domain in ataxin 3, which is expanded in spinocerebellar ataxia type 3, allows normal ataxin 3 to interact with and deubiquitinate beclin 1 and thereby to promote autophagy.

Suggested Citation

  • Avraham Ashkenazi & Carla F. Bento & Thomas Ricketts & Mariella Vicinanza & Farah Siddiqi & Mariana Pavel & Ferdinando Squitieri & Maarten C. Hardenberg & Sara Imarisio & Fiona M. Menzies & David C. R, 2017. "Polyglutamine tracts regulate beclin 1-dependent autophagy," Nature, Nature, vol. 545(7652), pages 108-111, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7652:d:10.1038_nature22078
    DOI: 10.1038/nature22078
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    Cited by:

    1. Joanne Watson & Harriet R. Ferguson & Rosie M. Brady & Jennifer Ferguson & Paul Fullwood & Hanyi Mo & Katherine H. Bexley & David Knight & Gareth Howell & Jean-Marc Schwartz & Michael P. Smith & Chiar, 2022. "Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Patricia González-Rodríguez & Daniel J. Klionsky & Bertrand Joseph, 2022. "Autophagy regulation by RNA alternative splicing and implications in human diseases," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Lidia Wrobel & Sandra M. Hill & Alvin Djajadikerta & Marian Fernandez-Estevez & Cansu Karabiyik & Avraham Ashkenazi & Victoria J. Barratt & Eleanna Stamatakou & Anders Gunnarsson & Timothy Rasmusson &, 2022. "Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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