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High-avidity IgA protects the intestine by enchaining growing bacteria

Author

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  • Kathrin Moor

    (Institute of Microbiology, ETH Zürich
    †Present addresses: Center for Dental Medicine, University of Zürich, Zürich, Switzerland (K.M.); Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy (C.C.).)

  • Médéric Diard

    (Institute of Microbiology, ETH Zürich)

  • Mikael E. Sellin

    (Institute of Microbiology, ETH Zürich
    Science for Life Laboratory, Uppsala University)

  • Boas Felmy

    (Institute of Microbiology, ETH Zürich)

  • Sandra Y. Wotzka

    (Institute of Microbiology, ETH Zürich)

  • Albulena Toska

    (Institute of Microbiology, ETH Zürich)

  • Erik Bakkeren

    (Institute of Microbiology, ETH Zürich)

  • Markus Arnoldini

    (Institute of Microbiology, ETH Zürich)

  • Florence Bansept

    (Laboratoire Jean Perrin (UMR 8237), CNRS - UPMC)

  • Alma Dal Co

    (ETH Zurich
    Eawag, Swiss Federal Institute of Aquatic Science and Technology)

  • Tom Völler

    (Institute of Microbiology, ETH Zürich)

  • Andrea Minola

    (Humabs BioMed SA)

  • Blanca Fernandez-Rodriguez

    (Institute for Research in Biomedicine)

  • Gloria Agatic

    (Humabs BioMed SA)

  • Sonia Barbieri

    (Institute for Research in Biomedicine)

  • Luca Piccoli

    (Institute for Research in Biomedicine)

  • Costanza Casiraghi

    (Institute for Research in Biomedicine
    †Present addresses: Center for Dental Medicine, University of Zürich, Zürich, Switzerland (K.M.); Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy (C.C.).)

  • Davide Corti

    (Humabs BioMed SA)

  • Antonio Lanzavecchia

    (Institute of Microbiology, ETH Zürich
    Institute for Research in Biomedicine)

  • Roland R. Regoes

    (Institute of Integrative Biology, ETH Zürich)

  • Claude Loverdo

    (Laboratoire Jean Perrin (UMR 8237), CNRS - UPMC)

  • Roman Stocker

    (Institute of Environmental Engineering, Environmental, and Geomatic Engineering, ETH Zürich)

  • Douglas R. Brumley

    (Institute of Environmental Engineering, Environmental, and Geomatic Engineering, ETH Zürich
    School of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria 3010, Australia)

  • Wolf-Dietrich Hardt

    (Institute of Microbiology, ETH Zürich)

  • Emma Slack

    (Institute of Microbiology, ETH Zürich)

Abstract

Oral-vaccine-induced IgA cross-links growing bacteria into clonal aggregates, inhibiting pathogenesis, adaption and the spread of antimicrobial resistance genes.

Suggested Citation

  • Kathrin Moor & Médéric Diard & Mikael E. Sellin & Boas Felmy & Sandra Y. Wotzka & Albulena Toska & Erik Bakkeren & Markus Arnoldini & Florence Bansept & Alma Dal Co & Tom Völler & Andrea Minola & Blan, 2017. "High-avidity IgA protects the intestine by enchaining growing bacteria," Nature, Nature, vol. 544(7651), pages 498-502, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7651:d:10.1038_nature22058
    DOI: 10.1038/nature22058
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    Cited by:

    1. Qianqiao Liu & Beth M. Stadtmueller, 2023. "SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Cyril Planchais & Luis M. Molinos-Albert & Pierre Rosenbaum & Thierry Hieu & Alexia Kanyavuz & Dominique Clermont & Thierry Prazuck & Laurent Lefrou & Jordan D. Dimitrov & Sophie Hüe & Laurent Hocquel, 2023. "HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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