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Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Author

Listed:
  • Oliver D. K. Maddocks

    (Cancer Research UK Beatson Institute
    University of Glasgow Institute of Cancer Sciences)

  • Dimitris Athineos

    (Cancer Research UK Beatson Institute)

  • Eric C. Cheung

    (Cancer Research UK Beatson Institute)

  • Pearl Lee

    (Cancer Research UK Beatson Institute
    †Present addresses: Abrahamson Family Cancer Research Institute, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA (P.L.); Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany (F.C.); The Crick Institute, 1 Midland Road, London NW1 1AT, UK (K.H.V.).)

  • Tong Zhang

    (University of Glasgow Institute of Cancer Sciences)

  • Niels J. F. van den Broek

    (Cancer Research UK Beatson Institute)

  • Gillian M. Mackay

    (Cancer Research UK Beatson Institute)

  • Christiaan F. Labuschagne

    (Cancer Research UK Beatson Institute)

  • David Gay

    (Cancer Research UK Beatson Institute)

  • Flore Kruiswijk

    (Cancer Research UK Beatson Institute)

  • Julianna Blagih

    (Cancer Research UK Beatson Institute)

  • David F. Vincent

    (Cancer Research UK Beatson Institute)

  • Kirsteen J. Campbell

    (Cancer Research UK Beatson Institute)

  • Fatih Ceteci

    (Cancer Research UK Beatson Institute
    †Present addresses: Abrahamson Family Cancer Research Institute, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA (P.L.); Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany (F.C.); The Crick Institute, 1 Midland Road, London NW1 1AT, UK (K.H.V.).)

  • Owen J. Sansom

    (Cancer Research UK Beatson Institute
    University of Glasgow Institute of Cancer Sciences)

  • Karen Blyth

    (Cancer Research UK Beatson Institute)

  • Karen H. Vousden

    (Cancer Research UK Beatson Institute
    †Present addresses: Abrahamson Family Cancer Research Institute, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA (P.L.); Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany (F.C.); The Crick Institute, 1 Midland Road, London NW1 1AT, UK (K.H.V.).)

Abstract

Dependence on exogenous serine means that tumour growth is restricted in mice on a low-serine diet; this effect on tumour growth can be amplified by antagonizing the antioxidant response.

Suggested Citation

  • Oliver D. K. Maddocks & Dimitris Athineos & Eric C. Cheung & Pearl Lee & Tong Zhang & Niels J. F. van den Broek & Gillian M. Mackay & Christiaan F. Labuschagne & David Gay & Flore Kruiswijk & Julianna, 2017. "Modulating the therapeutic response of tumours to dietary serine and glycine starvation," Nature, Nature, vol. 544(7650), pages 372-376, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7650:d:10.1038_nature22056
    DOI: 10.1038/nature22056
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