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Rad51-mediated double-strand break repair and mismatch correction of divergent substrates

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Listed:
  • Ranjith Anand

    (Brandeis University
    †Present address: Ginkgo Bioworks, Boston, Massachusetts 02210, USA.)

  • Annette Beach

    (Brandeis University)

  • Kevin Li

    (Brandeis University)

  • James Haber

    (Brandeis University)

Abstract

DNA repair by break-induced replication begins with the Rad51-mediated invasion of single-stranded DNA into a double-stranded donor template; this study shows that successful recombination between highly mismatched substrates can occur when only five consecutive bases can be paired and that mismatch correction is most efficient near the invading end of the recipient strand.

Suggested Citation

  • Ranjith Anand & Annette Beach & Kevin Li & James Haber, 2017. "Rad51-mediated double-strand break repair and mismatch correction of divergent substrates," Nature, Nature, vol. 544(7650), pages 377-380, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7650:d:10.1038_nature22046
    DOI: 10.1038/nature22046
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    Cited by:

    1. Amr M. Al-Zain & Mattie R. Nester & Iffat Ahmed & Lorraine S. Symington, 2023. "Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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