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DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome

Author

Listed:
  • Tuğçe Aktaş

    (Max Planck Institute of Immunobiology and Epigenetics)

  • İbrahim Avşar Ilık

    (Max Planck Institute of Immunobiology and Epigenetics)

  • Daniel Maticzka

    (Institute for Informatics, Albert-Ludwigs-University)

  • Vivek Bhardwaj

    (Max Planck Institute of Immunobiology and Epigenetics
    Faculty of Biology, University of Freiburg)

  • Cecilia Pessoa Rodrigues

    (Max Planck Institute of Immunobiology and Epigenetics
    Faculty of Biology, University of Freiburg)

  • Gerhard Mittler

    (Max Planck Institute of Immunobiology and Epigenetics)

  • Thomas Manke

    (Max Planck Institute of Immunobiology and Epigenetics)

  • Rolf Backofen

    (Institute for Informatics, Albert-Ludwigs-University)

  • Asifa Akhtar

    (Max Planck Institute of Immunobiology and Epigenetics)

Abstract

In the absence of DHX9, circular RNAs accumulate and transcription and translation are dysregulated—effects that are exacerbated by concomitant depletion of the RNA-editing enzyme ADAR.

Suggested Citation

  • Tuğçe Aktaş & İbrahim Avşar Ilık & Daniel Maticzka & Vivek Bhardwaj & Cecilia Pessoa Rodrigues & Gerhard Mittler & Thomas Manke & Rolf Backofen & Asifa Akhtar, 2017. "DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome," Nature, Nature, vol. 544(7648), pages 115-119, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7648:d:10.1038_nature21715
    DOI: 10.1038/nature21715
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    Citations

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    Cited by:

    1. Steffen Fuchs & Clara Danßmann & Filippos Klironomos & Annika Winkler & Jörg Fallmann & Louisa-Marie Kruetzfeldt & Annabell Szymansky & Julian Naderi & Stephan H. Bernhart & Laura Grunewald & Konstant, 2023. "Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Haoqing Shen & Omer An & Xi Ren & Yangyang Song & Sze Jing Tang & Xin-Yu Ke & Jian Han & Daryl Jin Tai Tay & Vanessa Hui En Ng & Fernando Bellido Molias & Priyankaa Pitcheshwar & Ka Wai Leong & Ker-Ka, 2022. "ADARs act as potent regulators of circular transcriptome in cancer," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Jia Song & Wei Zhao & Xin Zhang & Wenyu Tian & Xuyang Zhao & Liang Ma & Yongtong Cao & Yuxin Yin & Xuehui Zhang & Xuliang Deng & Dan Lu, 2022. "Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Peng Wang & Zhitao Huang & Yili Peng & Hongwei Li & Tong Lin & Yingyu Zhao & Zheng Hu & Zhanmei Zhou & Weijie Zhou & Youhua Liu & Fan Fan Hou, 2022. "Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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