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Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

Author

Listed:
  • Young Seok Ju

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology)

  • Inigo Martincorena

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Moritz Gerstung

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    European Molecular Biology Laboratory, European Bioinformatics Institute)

  • Mia Petljak

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Ludmil B. Alexandrov

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    Theoretical Biology and Biophysics (T-6), Los Alamos National Laboratory)

  • Raheleh Rahbari

    (Genomic Mutation and Genetic Disease, Wellcome Trust Sanger Institute)

  • David C. Wedge

    (Cancer Genome Project, Wellcome Trust Sanger Institute
    Oxford Big Data Institute and Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics)

  • Helen R. Davies

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Manasa Ramakrishna

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Anthony Fullam

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sancha Martin

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Christopher Alder

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Nikita Patel

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Steve Gamble

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Sarah O’Meara

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Dilip D. Giri

    (Memorial Sloan-Kettering Cancer Center)

  • Torril Sauer

    (Institute of Clinical Medicine, Campus at Akershus University Hospital, University of Oslo)

  • Sarah E. Pinder

    (King’s Health Partners Cancer Biobank, Guy’s Hospital, King’s College London School of Medicine)

  • Colin A. Purdie

    (Ninewells Hospital and Medical School)

  • Åke Borg

    (BioCare, Strategic Cancer Research Program
    CREATE Health, Strategic Centre for Translational Cancer Research
    Lund University Cancer Center)

  • Henk Stunnenberg

    (Radboud University Medical Center)

  • Marc van de Vijver

    (Academic Medical Center)

  • Benita K. T. Tan

    (SingHealth Duke-NUS Breast Centre, National Cancer Centre Singapore, Singapore General Hospital)

  • Carlos Caldas

    (Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge)

  • Andrew Tutt

    (Breast Cancer Now Research Unit, King’s College London
    Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research)

  • Naoto T. Ueno

    (The University of Texas MD Anderson Cancer Center)

  • Laura J. van ’t Veer

    (Helen Diller Family Comprehensive Cancer Center, University of California)

  • John W. M. Martens

    (Erasmus MC Cancer Institute, Erasmus University Medical Center)

  • Christos Sotiriou

    (Institut Jules Bordet)

  • Stian Knappskog

    (Section of Oncology, University of Bergen
    Haukeland University Hospital)

  • Paul N. Span

    (Radboud University Medical Center)

  • Sunil R. Lakhani

    (University of Queensland, School of Medicine
    Pathology Queensland, Royal Brisbane and Women’s Hospital
    University of Queensland, UQ Centre for Clinical Research)

  • Jórunn Erla Eyfjörd

    (Cancer Research Laboratory, University of Iceland)

  • Anne-Lise Børresen-Dale

    (Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital
    The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo)

  • Andrea Richardson

    (Johns Hopkins Medicine)

  • Alastair M. Thompson

    (The University of Texas MD Anderson Cancer Center)

  • Alain Viari

    (Plateforme Gilles Thomas, Synergie Lyon Cancer, Centre Léon Bérard)

  • Matthew E. Hurles

    (Genomic Mutation and Genetic Disease, Wellcome Trust Sanger Institute)

  • Serena Nik-Zainal

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Peter J. Campbell

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

  • Michael R. Stratton

    (Cancer Genome Project, Wellcome Trust Sanger Institute)

Abstract

Whole-genome sequencing of normal blood cells sampled from 241 adults is used to infer mosaic point mutations that are likely to have arisen during early embryogenesis, providing insight into how early cellular dynamics may affect adult tissues.

Suggested Citation

  • Young Seok Ju & Inigo Martincorena & Moritz Gerstung & Mia Petljak & Ludmil B. Alexandrov & Raheleh Rahbari & David C. Wedge & Helen R. Davies & Manasa Ramakrishna & Anthony Fullam & Sancha Martin & C, 2017. "Somatic mutations reveal asymmetric cellular dynamics in the early human embryo," Nature, Nature, vol. 543(7647), pages 714-718, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7647:d:10.1038_nature21703
    DOI: 10.1038/nature21703
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    Cited by:

    1. Oriol Pich & Iker Reyes-Salazar & Abel Gonzalez-Perez & Nuria Lopez-Bigas, 2022. "Discovering the drivers of clonal hematopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Marie Bernkopf & Ummi B. Abdullah & Stephen J. Bush & Katherine A. Wood & Sahar Ghaffari & Eleni Giannoulatou & Nils Koelling & Geoffrey J. Maher & Loïc M. Thibaut & Jonathan Williams & Edward M. Blai, 2023. "Personalized recurrence risk assessment following the birth of a child with a pathogenic de novo mutation," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Thomas R. W. Oliver & Lia Chappell & Rashesh Sanghvi & Lauren Deighton & Naser Ansari-Pour & Stefan C. Dentro & Matthew D. Young & Tim H. H. Coorens & Hyunchul Jung & Tim Butler & Matthew D. C. Nevill, 2022. "Clonal diversification and histogenesis of malignant germ cell tumours," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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