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Effective combinatorial immunotherapy for castration-resistant prostate cancer

Author

Listed:
  • Xin Lu

    (The University of Texas MD Anderson Cancer Center
    † Present address: Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.)

  • James W. Horner

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Erin Paul

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Xiaoying Shang

    (The University of Texas MD Anderson Cancer Center)

  • Patricia Troncoso

    (The University of Texas MD Anderson Cancer Center)

  • Pingna Deng

    (The University of Texas MD Anderson Cancer Center)

  • Shan Jiang

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Qing Chang

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Denise J. Spring

    (The University of Texas MD Anderson Cancer Center)

  • Padmanee Sharma

    (The University of Texas MD Anderson Cancer Center)

  • John A. Zebala

    (Syntrix Biosystems, Inc.)

  • Dean Y. Maeda

    (Syntrix Biosystems, Inc.)

  • Y. Alan Wang

    (The University of Texas MD Anderson Cancer Center)

  • Ronald A. DePinho

    (The University of Texas MD Anderson Cancer Center)

Abstract

A new chimaeric mouse model of metastatic castration-resistant prostate cancer to efficiently test combination therapies in an autochthonous setting.

Suggested Citation

  • Xin Lu & James W. Horner & Erin Paul & Xiaoying Shang & Patricia Troncoso & Pingna Deng & Shan Jiang & Qing Chang & Denise J. Spring & Padmanee Sharma & John A. Zebala & Dean Y. Maeda & Y. Alan Wang &, 2017. "Effective combinatorial immunotherapy for castration-resistant prostate cancer," Nature, Nature, vol. 543(7647), pages 728-732, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7647:d:10.1038_nature21676
    DOI: 10.1038/nature21676
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    Cited by:

    1. Ni Li & Qiuli Liu & Ying Han & Siyu Pei & Bisheng Cheng & Junyu Xu & Xiang Miao & Qiang Pan & Hanling Wang & Jiacheng Guo & Xuege Wang & Guoying Zhang & Yannan Lian & Wei Zhang & Yi Zang & Minjia Tan , 2022. "ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Anwaar Saeed & Robin Park & Harsh Pathak & Ayah Nedal Al-Bzour & Junqiang Dai & Milind Phadnis & Raed Al-Rajabi & Anup Kasi & Joaquina Baranda & Weijing Sun & Stephen Williamson & Yu-Chiao Chiu & Hati, 2024. "Clinical and biomarker results from a phase II trial of combined cabozantinib and durvalumab in patients with chemotherapy-refractory colorectal cancer (CRC): CAMILLA CRC cohort," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Dhivya Sridaran & Surbhi Chouhan & Kiran Mahajan & Arun Renganathan & Cody Weimholt & Shambhavi Bhagwat & Melissa Reimers & Eric H. Kim & Manish K. Thakur & Muhammad A. Saeed & Russell K. Pachynski & , 2022. "Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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