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Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

Author

Listed:
  • Brandy Verhalen

    (Vanderbilt University
    † Present address: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.)

  • Reza Dastvan

    (Vanderbilt University)

  • Sundarapandian Thangapandian

    (Center for Biophysics and Quantitative Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign)

  • Yelena Peskova

    (University of Virginia)

  • Hanane A. Koteiche

    (Vanderbilt University)

  • Robert K. Nakamoto

    (University of Virginia)

  • Emad Tajkhorshid

    (Center for Biophysics and Quantitative Biology, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign)

  • Hassane S. Mchaourab

    (Vanderbilt University)

Abstract

Double electron–electron resonance and computer simulations are used to describe conformational dynamics in the ATP-binding cassette transporter Pgp, which has an important role in the clearance of xenobiotics and cancer resistance to chemotherapy.

Suggested Citation

  • Brandy Verhalen & Reza Dastvan & Sundarapandian Thangapandian & Yelena Peskova & Hanane A. Koteiche & Robert K. Nakamoto & Emad Tajkhorshid & Hassane S. Mchaourab, 2017. "Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein," Nature, Nature, vol. 543(7647), pages 738-741, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7647:d:10.1038_nature21414
    DOI: 10.1038/nature21414
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    Cited by:

    1. Reza Dastvan & Ali Rasouli & Sepehr Dehghani-Ghahnaviyeh & Samantha Gies & Emad Tajkhorshid, 2022. "Proton-driven alternating access in a spinster lipid transporter," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ruojing Zhang & Kevin L. Jagessar & Matthew Brownd & Adithya Polasa & Richard A. Stein & Mahmoud Moradi & Erkan Karakas & Hassane S. Mchaourab, 2024. "Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Qingyu Tang & Matt Sinclair & Hale S. Hasdemir & Richard A. Stein & Erkan Karakas & Emad Tajkhorshid & Hassane S. Mchaourab, 2023. "Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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