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CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

Author

Listed:
  • Benjamin Descours

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, UMR9002, CNRS, Université de Montpellier)

  • Gaël Petitjean

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, UMR9002, CNRS, Université de Montpellier)

  • José-Luis López-Zaragoza

    (Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955, and Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique
    Inserm, U955
    AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique et Maladies Infectieuses)

  • Timothée Bruel

    (Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955, and Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique
    Institut Pasteur, Virus and Immunity Unit)

  • Raoul Raffel

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, UMR9002, CNRS, Université de Montpellier)

  • Christina Psomas

    (Hôpital Universitaire)

  • Jacques Reynes

    (Hôpital Universitaire)

  • Christine Lacabaratz

    (Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955, and Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique
    Inserm, U955
    AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique et Maladies Infectieuses)

  • Yves Levy

    (Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955, and Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique
    Inserm, U955
    AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique et Maladies Infectieuses)

  • Olivier Schwartz

    (Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955, and Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique
    Institut Pasteur, Virus and Immunity Unit)

  • Jean Daniel Lelievre

    (Vaccine Research Institute, Université Paris-Est, Faculté de Médecine, INSERM U955, and Assistance Publique-Hôpitaux de Paris, Groupe Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique
    Inserm, U955
    AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d’Immunologie Clinique et Maladies Infectieuses)

  • Monsef Benkirane

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, UMR9002, CNRS, Université de Montpellier)

Abstract

CD32a expression is induced on the surface of HIV-1-infected quiescent CD4 T cells, and could thus be used as a biomarker to facilitate future study of how the virus persists in cellular reservoirs in infected hosts.

Suggested Citation

  • Benjamin Descours & Gaël Petitjean & José-Luis López-Zaragoza & Timothée Bruel & Raoul Raffel & Christina Psomas & Jacques Reynes & Christine Lacabaratz & Yves Levy & Olivier Schwartz & Jean Daniel Le, 2017. "CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses," Nature, Nature, vol. 543(7646), pages 564-567, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7646:d:10.1038_nature21710
    DOI: 10.1038/nature21710
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    Cited by:

    1. Caroline Dufour & Corentin Richard & Marion Pardons & Marta Massanella & Antoine Ackaoui & Ben Murrell & Bertrand Routy & Réjean Thomas & Jean-Pierre Routy & Rémi Fromentin & Nicolas Chomont, 2023. "Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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