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DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs

Author

Listed:
  • Masashi Yamaji

    (Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University)

  • Miki Jishage

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

  • Cindy Meyer

    (Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University)

  • Hemant Suryawanshi

    (Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University)

  • Evan Der

    (Albert Einstein College of Medicine)

  • Misaki Yamaji

    (Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University)

  • Aitor Garzia

    (Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University)

  • Pavel Morozov

    (Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University)

  • Sudhir Manickavel

    (Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease)

  • Hannah L. McFarland

    (Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease)

  • Robert G. Roeder

    (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University)

  • Markus Hafner

    (Laboratory of Muscle Stem Cells and Gene Regulation, National Institute for Arthritis and Musculoskeletal and Skin Disease)

  • Thomas Tuschl

    (Howard Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University)

Abstract

The vertebrate-conserved and germline-specific RNA-binding protein DND1 recruits the CCR4–NOT deadenylase complex to destabilize its mRNA targets and is required for the maintenance of germline stem cells.

Suggested Citation

  • Masashi Yamaji & Miki Jishage & Cindy Meyer & Hemant Suryawanshi & Evan Der & Misaki Yamaji & Aitor Garzia & Pavel Morozov & Sudhir Manickavel & Hannah L. McFarland & Robert G. Roeder & Markus Hafner , 2017. "DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs," Nature, Nature, vol. 543(7646), pages 568-572, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7646:d:10.1038_nature21690
    DOI: 10.1038/nature21690
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    Cited by:

    1. Hasan Vatandaslar & Aitor Garzia & Cindy Meyer & Svenja Godbersen & Laura T. L. Brandt & Esther Griesbach & Jeffrey A. Chao & Thomas Tuschl & Markus Stoffel, 2023. "In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets regulating cholesterol synthesis and secretion," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Malgorzata M. Duszczyk & Harry Wischnewski & Tamara Kazeeva & Rajika Arora & Fionna E. Loughlin & Christine Schroetter & Ugo Pradère & Jonathan Hall & Constance Ciaudo & Frédéric H.-T. Allain, 2022. "The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Monika Graf & Marta Interlandi & Natalia Moreno & Dörthe Holdhof & Carolin Göbel & Viktoria Melcher & Julius Mertins & Thomas K. Albert & Dennis Kastrati & Amelie Alfert & Till Holsten & Flavia de Far, 2022. "Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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