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Interplay between metabolic identities in the intestinal crypt supports stem cell function

Author

Listed:
  • Maria J. Rodríguez-Colman

    (Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht)

  • Matthias Schewe

    (Erasmus MC Cancer Institute, Erasmus University Medical Center)

  • Maaike Meerlo

    (Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht)

  • Edwin Stigter

    (Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht)

  • Johan Gerrits

    (Department of Genetics and Center for Molecular Medicine)

  • Mia Pras-Raves

    (Department of Genetics and Center for Molecular Medicine)

  • Andrea Sacchetti

    (Erasmus MC Cancer Institute, Erasmus University Medical Center)

  • Marten Hornsveld

    (Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht)

  • Koen C. Oost

    (Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht)

  • Hugo J. Snippert

    (Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht)

  • Nanda Verhoeven-Duif

    (Department of Genetics and Center for Molecular Medicine)

  • Riccardo Fodde

    (Erasmus MC Cancer Institute, Erasmus University Medical Center)

  • Boudewijn M. T. Burgering

    (Molecular Cancer Research, Center Molecular Medicine, University Medical Center Utrecht)

Abstract

The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP kinase, ensuring regeneration of a mature crypt.

Suggested Citation

  • Maria J. Rodríguez-Colman & Matthias Schewe & Maaike Meerlo & Edwin Stigter & Johan Gerrits & Mia Pras-Raves & Andrea Sacchetti & Marten Hornsveld & Koen C. Oost & Hugo J. Snippert & Nanda Verhoeven-D, 2017. "Interplay between metabolic identities in the intestinal crypt supports stem cell function," Nature, Nature, vol. 543(7645), pages 424-427, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7645:d:10.1038_nature21673
    DOI: 10.1038/nature21673
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    Cited by:

    1. Ozren Stojanović & Jordi Altirriba & Dorothée Rigo & Martina Spiljar & Emilien Evrard & Benedek Roska & Salvatore Fabbiano & Nicola Zamboni & Pierre Maechler & Françoise Rohner-Jeanrenaud & Mirko Traj, 2021. "Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Shuting Li & Chia-Wen Lu & Elia C. Diem & Wang Li & Melanie Guderian & Marc Lindenberg & Friederike Kruse & Manuela Buettner & Stefan Floess & Markus R. Winny & Robert Geffers & Hans-Hermann Richnow &, 2022. "Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Carlos Sebastian & Christina Ferrer & Maria Serra & Jee-Eun Choi & Nadia Ducano & Alessia Mira & Manasvi S. Shah & Sylwia A. Stopka & Andrew J. Perciaccante & Claudio Isella & Daniel Moya-Rull & Maria, 2022. "A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Y. Wang & E. R. Zoneff & J. W. Thomas & N. Hong & L. L. Tan & D. J. McGillivray & A. W. Perriman & K. C. L. Law & L. H. Thompson & N. Moriarty & C. L. Parish & R. J. Williams & C. J. Jackson & D. R. N, 2023. "Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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