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KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Author

Listed:
  • Rachel L. Wolfson

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Lynne Chantranupong

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Gregory A. Wyant

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Xin Gu

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Jose M. Orozco

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Kuang Shen

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Kendall J. Condon

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Sabrina Petri

    (Columbia University Medical Center)

  • Jibril Kedir

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Sonia M. Scaria

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Monther Abu-Remaileh

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Wayne N. Frankel

    (Columbia University Medical Center)

  • David M. Sabatini

    (Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center)

Abstract

A protein complex composed of KPTN, ITFG2, C12orf66 and SZT2, named KICSTOR, is necessary for lysosomal localization of GATOR1, interaction of GATOR1 with the Rag GTPases and GATOR2, and nutrient-dependent mTORC1 modulation.

Suggested Citation

  • Rachel L. Wolfson & Lynne Chantranupong & Gregory A. Wyant & Xin Gu & Jose M. Orozco & Kuang Shen & Kendall J. Condon & Sabrina Petri & Jibril Kedir & Sonia M. Scaria & Monther Abu-Remaileh & Wayne N., 2017. "KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1," Nature, Nature, vol. 543(7645), pages 438-442, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7645:d:10.1038_nature21423
    DOI: 10.1038/nature21423
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    Citations

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    Cited by:

    1. Tianyu Zhao & Yuanyuan Guan & Chenchen Xu & Dong Wang & Jialiang Guan & Ying Liu, 2023. "VWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Grace Y. Liu & Patrick Jouandin & Raymond E. Bahng & Norbert Perrimon & David M. Sabatini, 2024. "An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Xing Chen & Chunyu Yu & Xinhua Liu & Beibei Liu & Xiaodi Wu & Jiajing Wu & Dong Yan & Lulu Han & Zifan Tang & Xinyi Yuan & Jianqiu Wang & Yue Wang & Shumeng Liu & Lin Shan & Yongfeng Shang, 2022. "Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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