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SZT2 dictates GATOR control of mTORC1 signalling

Author

Listed:
  • Min Peng

    (Immunology Program, Memorial Sloan Kettering Cancer Center)

  • Na Yin

    (Immunology Program, Memorial Sloan Kettering Cancer Center)

  • Ming O. Li

    (Immunology Program, Memorial Sloan Kettering Cancer Center)

Abstract

SZT2 recruits GATOR1 and GATOR2 to form a SZT2-orchestrated GATOR (SOG) complex at the lysosome that is essential for GATOR- and SESN-dependent nutrient sensing and mTORC1 regulation.

Suggested Citation

  • Min Peng & Na Yin & Ming O. Li, 2017. "SZT2 dictates GATOR control of mTORC1 signalling," Nature, Nature, vol. 543(7645), pages 433-437, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7645:d:10.1038_nature21378
    DOI: 10.1038/nature21378
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    Cited by:

    1. Tianyu Zhao & Yuanyuan Guan & Chenchen Xu & Dong Wang & Jialiang Guan & Ying Liu, 2023. "VWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Grace Y. Liu & Patrick Jouandin & Raymond E. Bahng & Norbert Perrimon & David M. Sabatini, 2024. "An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Xing Chen & Chunyu Yu & Xinhua Liu & Beibei Liu & Xiaodi Wu & Jiajing Wu & Dong Yan & Lulu Han & Zifan Tang & Xinyi Yuan & Jianqiu Wang & Yue Wang & Shumeng Liu & Lin Shan & Yongfeng Shang, 2022. "Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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