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Transcription control by the ENL YEATS domain in acute leukaemia

Author

Listed:
  • Michael A. Erb

    (Dana-Farber Cancer Institute)

  • Thomas G. Scott

    (Dana-Farber Cancer Institute)

  • Bin E. Li

    (Boston Children’s Hospital
    Dana-Farber Cancer Institute
    Harvard Stem Cell Institute, Harvard Medical School)

  • Huafeng Xie

    (Boston Children’s Hospital
    Dana-Farber Cancer Institute
    Harvard Stem Cell Institute, Harvard Medical School)

  • Joshiawa Paulk

    (Dana-Farber Cancer Institute)

  • Hyuk-Soo Seo

    (Dana-Farber Cancer Institute)

  • Amanda Souza

    (Dana-Farber Cancer Institute)

  • Justin M. Roberts

    (Dana-Farber Cancer Institute)

  • Shiva Dastjerdi

    (Dana-Farber Cancer Institute)

  • Dennis L. Buckley

    (Dana-Farber Cancer Institute)

  • Neville E. Sanjana

    (Broad Institute, 7 Cambridge Center
    McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Ophir Shalem

    (Broad Institute, 7 Cambridge Center
    McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Behnam Nabet

    (Dana-Farber Cancer Institute)

  • Rhamy Zeid

    (Dana-Farber Cancer Institute)

  • Nana K. Offei-Addo

    (Dana-Farber Cancer Institute)

  • Sirano Dhe-Paganon

    (Dana-Farber Cancer Institute)

  • Feng Zhang

    (Broad Institute, 7 Cambridge Center
    McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Stuart H. Orkin

    (Boston Children’s Hospital
    Dana-Farber Cancer Institute
    Harvard Stem Cell Institute, Harvard Medical School
    Howard Hughes Medical Institute, Boston Children’s Hospital)

  • Georg E. Winter

    (Dana-Farber Cancer Institute
    † Present addresses: Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria (G.E.W.); Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA (J.E.B.).)

  • James E. Bradner

    (Dana-Farber Cancer Institute
    Harvard Medical School
    † Present addresses: Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria (G.E.W.); Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA (J.E.B.).)

Abstract

ENL, identified in a genome-scale loss-of-function screen as a crucial requirement for proliferation of acute leukaemia, is required for leukaemic gene expression, and its YEATS chromatin-reader domain is essential for leukaemic growth.

Suggested Citation

  • Michael A. Erb & Thomas G. Scott & Bin E. Li & Huafeng Xie & Joshiawa Paulk & Hyuk-Soo Seo & Amanda Souza & Justin M. Roberts & Shiva Dastjerdi & Dennis L. Buckley & Neville E. Sanjana & Ophir Shalem , 2017. "Transcription control by the ENL YEATS domain in acute leukaemia," Nature, Nature, vol. 543(7644), pages 270-274, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7644:d:10.1038_nature21688
    DOI: 10.1038/nature21688
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    Citations

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    Cited by:

    1. Daniel P. Bondeson & Zachary Mullin-Bernstein & Sydney Oliver & Thomas A. Skipper & Thomas C. Atack & Nolan Bick & Meilani Ching & Andrew A. Guirguis & Jason Kwon & Carly Langan & Dylan Millson & Bren, 2022. "Systematic profiling of conditional degron tag technologies for target validation studies," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Christoph Grohmann & Charlene M. Magtoto & Joel R. Walker & Ngee Kiat Chua & Anna Gabrielyan & Mary Hall & Simon A. Cobbold & Stephen Mieruszynski & Martin Brzozowski & Daniel S. Simpson & Hao Dong & , 2022. "Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Derek H. Janssens & Melodie Duran & Dominik J. Otto & Weifang Wu & Yiling Xu & Danielle Kirkey & Charles G. Mullighan & Joanna S. Yi & Soheil Meshinchi & Jay F. Sarthy & Kami Ahmad & Steven Henikoff, 2024. "MLL oncoprotein levels influence leukemia lineage identities," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Yosuke Komata & Akinori Kanai & Takahiro Maeda & Toshiya Inaba & Akihiko Yokoyama, 2023. "MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Lele Song & Qinglan Li & Lingbo Xia & Arushi Eesha Sahay & Qi Qiu & Yuanyuan Li & Haitao Li & Kotaro Sasaki & Katalin Susztak & Hao Wu & Liling Wan, 2024. "Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape," Nature Communications, Nature, vol. 15(1), pages 1-26, December.

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