IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v543y2017i7644d10.1038_nature21687.html
   My bibliography  Save this article

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

Author

Listed:
  • Liling Wan

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    Dana-Farber Cancer Institute, Harvard Medical School)

  • Hong Wen

    (The University of Texas MD Anderson Cancer Center
    Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center)

  • Yuanyuan Li

    (Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University)

  • Jie Lyu

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Yuanxin Xi

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Takayuki Hoshii

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    Dana-Farber Cancer Institute, Harvard Medical School)

  • Julia K. Joseph

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University)

  • Xiaolu Wang

    (The University of Texas MD Anderson Cancer Center)

  • Yong-Hwee E. Loh

    (Icahn School of Medicine at Mount Sinai)

  • Michael A. Erb

    (Dana-Farber Cancer Institute)

  • Amanda L. Souza

    (Dana-Farber Cancer Institute
    † Present addresses: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA (A.L.S., J.E.B.).)

  • James E. Bradner

    (Dana-Farber Cancer Institute
    Harvard Medical School
    † Present addresses: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA (A.L.S., J.E.B.).)

  • Li Shen

    (Icahn School of Medicine at Mount Sinai)

  • Wei Li

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Haitao Li

    (Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University)

  • C. David Allis

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University)

  • Scott A. Armstrong

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    Dana-Farber Cancer Institute, Harvard Medical School)

  • Xiaobing Shi

    (The University of Texas MD Anderson Cancer Center
    Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center
    Genes and Development and Epigenetics & Molecular Carcinogenesis Graduate Programs, The University of Texas Graduate School of Biomedical Sciences)

Abstract

The chromatin-reader protein ENL regulates oncogenic programs in acute myeloid leukaemia by binding via its YEATS domain to acetylated histones on the promoters of actively transcribed genes and recruiting the transcriptional machinery.

Suggested Citation

  • Liling Wan & Hong Wen & Yuanyuan Li & Jie Lyu & Yuanxin Xi & Takayuki Hoshii & Julia K. Joseph & Xiaolu Wang & Yong-Hwee E. Loh & Michael A. Erb & Amanda L. Souza & James E. Bradner & Li Shen & Wei Li, 2017. "ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia," Nature, Nature, vol. 543(7644), pages 265-269, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7644:d:10.1038_nature21687
    DOI: 10.1038/nature21687
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature21687
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature21687?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Steffen Mueller & Gail Dennison & Shujun Liu, 2021. "An Assessment on Ethanol-Blended Gasoline/Diesel Fuels on Cancer Risk and Mortality," IJERPH, MDPI, vol. 18(13), pages 1-23, June.
    2. Lele Song & Qinglan Li & Lingbo Xia & Arushi Eesha Sahay & Qi Qiu & Yuanyuan Li & Haitao Li & Kotaro Sasaki & Katalin Susztak & Hao Wu & Liling Wan, 2024. "Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape," Nature Communications, Nature, vol. 15(1), pages 1-26, December.
    3. Zhe Wang & Xin Yang & Delin Chen & Yanqing Liu & Zhiming Li & Shoufu Duan & Zhiguo Zhang & Xuejun Jiang & Brent R. Stockwell & Wei Gu, 2024. "GAS41 modulates ferroptosis by anchoring NRF2 on chromatin," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Yosuke Komata & Akinori Kanai & Takahiro Maeda & Toshiya Inaba & Akihiko Yokoyama, 2023. "MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Duo Wang & Fuxiang Yan & Ping Wu & Kexue Ge & Muchun Li & Tingting Li & Ying Gao & Chao Peng & Yong Chen, 2022. "Global profiling of regulatory elements in the histone benzoylation pathway," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Shaela Wright & Xujie Zhao & Wojciech Rosikiewicz & Shelby Mryncza & Judith Hyle & Wenjie Qi & Zhenling Liu & Siqi Yi & Yong Cheng & Beisi Xu & Chunliang Li, 2023. "Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:543:y:2017:i:7644:d:10.1038_nature21687. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.