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ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

Author

Listed:
  • Liling Wan

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    Dana-Farber Cancer Institute, Harvard Medical School)

  • Hong Wen

    (The University of Texas MD Anderson Cancer Center
    Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center)

  • Yuanyuan Li

    (Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University)

  • Jie Lyu

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Yuanxin Xi

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Takayuki Hoshii

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    Dana-Farber Cancer Institute, Harvard Medical School)

  • Julia K. Joseph

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University)

  • Xiaolu Wang

    (The University of Texas MD Anderson Cancer Center)

  • Yong-Hwee E. Loh

    (Icahn School of Medicine at Mount Sinai)

  • Michael A. Erb

    (Dana-Farber Cancer Institute)

  • Amanda L. Souza

    (Dana-Farber Cancer Institute
    † Present addresses: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA (A.L.S., J.E.B.).)

  • James E. Bradner

    (Dana-Farber Cancer Institute
    Harvard Medical School
    † Present addresses: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA (A.L.S., J.E.B.).)

  • Li Shen

    (Icahn School of Medicine at Mount Sinai)

  • Wei Li

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Haitao Li

    (Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University)

  • C. David Allis

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University)

  • Scott A. Armstrong

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    Dana-Farber Cancer Institute, Harvard Medical School)

  • Xiaobing Shi

    (The University of Texas MD Anderson Cancer Center
    Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center
    Genes and Development and Epigenetics & Molecular Carcinogenesis Graduate Programs, The University of Texas Graduate School of Biomedical Sciences)

Abstract

The chromatin-reader protein ENL regulates oncogenic programs in acute myeloid leukaemia by binding via its YEATS domain to acetylated histones on the promoters of actively transcribed genes and recruiting the transcriptional machinery.

Suggested Citation

  • Liling Wan & Hong Wen & Yuanyuan Li & Jie Lyu & Yuanxin Xi & Takayuki Hoshii & Julia K. Joseph & Xiaolu Wang & Yong-Hwee E. Loh & Michael A. Erb & Amanda L. Souza & James E. Bradner & Li Shen & Wei Li, 2017. "ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia," Nature, Nature, vol. 543(7644), pages 265-269, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7644:d:10.1038_nature21687
    DOI: 10.1038/nature21687
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    Cited by:

    1. Steffen Mueller & Gail Dennison & Shujun Liu, 2021. "An Assessment on Ethanol-Blended Gasoline/Diesel Fuels on Cancer Risk and Mortality," IJERPH, MDPI, vol. 18(13), pages 1-23, June.
    2. Zhe Wang & Xin Yang & Delin Chen & Yanqing Liu & Zhiming Li & Shoufu Duan & Zhiguo Zhang & Xuejun Jiang & Brent R. Stockwell & Wei Gu, 2024. "GAS41 modulates ferroptosis by anchoring NRF2 on chromatin," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Yosuke Komata & Akinori Kanai & Takahiro Maeda & Toshiya Inaba & Akihiko Yokoyama, 2023. "MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Shaela Wright & Xujie Zhao & Wojciech Rosikiewicz & Shelby Mryncza & Judith Hyle & Wenjie Qi & Zhenling Liu & Siqi Yi & Yong Cheng & Beisi Xu & Chunliang Li, 2023. "Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Duo Wang & Fuxiang Yan & Ping Wu & Kexue Ge & Muchun Li & Tingting Li & Ying Gao & Chao Peng & Yong Chen, 2022. "Global profiling of regulatory elements in the histone benzoylation pathway," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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