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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

Author

Listed:
  • Norbert Pardi

    (Perelman School of Medicine, University of Pennsylvania)

  • Michael J. Hogan

    (Perelman School of Medicine, University of Pennsylvania)

  • Rebecca S. Pelc

    (Viral Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health)

  • Hiromi Muramatsu

    (Perelman School of Medicine, University of Pennsylvania)

  • Hanne Andersen

    (Bioqual Inc.)

  • Christina R. DeMaso

    (Viral Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health)

  • Kimberly A. Dowd

    (Viral Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health)

  • Laura L. Sutherland

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Richard M. Scearce

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Robert Parks

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Wendeline Wagner

    (Bioqual Inc.)

  • Alex Granados

    (Bioqual Inc.)

  • Jack Greenhouse

    (Bioqual Inc.)

  • Michelle Walker

    (Bioqual Inc.)

  • Elinor Willis

    (Perelman School of Medicine, University of Pennsylvania)

  • Jae-Sung Yu

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Charles E. McGee

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Gregory D. Sempowski

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Barbara L. Mui

    (Acuitas Therapeutics, Vancouver)

  • Ying K. Tam

    (Acuitas Therapeutics, Vancouver)

  • Yan-Jang Huang

    (Diagnostic Medicine and Pathobiology, College of Veterinary Medicine and the Biosecurity Research Institute, Kansas State University)

  • Dana Vanlandingham

    (Diagnostic Medicine and Pathobiology, College of Veterinary Medicine and the Biosecurity Research Institute, Kansas State University)

  • Veronica M. Holmes

    (Perelman School of Medicine, University of Pennsylvania)

  • Harikrishnan Balachandran

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Sujata Sahu

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Michelle Lifton

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Stephen Higgs

    (Diagnostic Medicine and Pathobiology, College of Veterinary Medicine and the Biosecurity Research Institute, Kansas State University)

  • Scott E. Hensley

    (Perelman School of Medicine, University of Pennsylvania)

  • Thomas D. Madden

    (Acuitas Therapeutics, Vancouver)

  • Michael J. Hope

    (Acuitas Therapeutics, Vancouver)

  • Katalin Karikó

    (BioNTech RNA Pharmaceuticals)

  • Sampa Santra

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Barney S. Graham

    (Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health)

  • Mark G. Lewis

    (Bioqual Inc.)

  • Theodore C. Pierson

    (Viral Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health)

  • Barton F. Haynes

    (Duke Human Vaccine Institute, Duke University School of Medicine)

  • Drew Weissman

    (Perelman School of Medicine, University of Pennsylvania)

Abstract

A single, low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside-modified mRNA encoding the pre-membrane and envelope glycoproteins of Zika virus protects both mice and rhesus macaques against infection and elicits rapid and long-lasting neutralizing antibody responses.

Suggested Citation

  • Norbert Pardi & Michael J. Hogan & Rebecca S. Pelc & Hiromi Muramatsu & Hanne Andersen & Christina R. DeMaso & Kimberly A. Dowd & Laura L. Sutherland & Richard M. Scearce & Robert Parks & Wendeline Wa, 2017. "Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination," Nature, Nature, vol. 543(7644), pages 248-251, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7644:d:10.1038_nature21428
    DOI: 10.1038/nature21428
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