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Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

Author

Listed:
  • Manoj K. Pandey

    (Cincinnati Children’s Hospital Medical Center)

  • Thomas A. Burrow

    (Cincinnati Children’s Hospital Medical Center)

  • Reena Rani

    (Cincinnati Children’s Hospital Medical Center)

  • Lisa J. Martin

    (Cincinnati Children’s Hospital Medical Center)

  • David Witte

    (Cincinnati Children’s Hospital Medical Center)

  • Kenneth D. Setchell

    (Laboratory of Mass Spectroscopy, Cincinnati Children’s Hospital Medical Center)

  • Mary A. Mckay

    (Cincinnati Children’s Hospital Medical Center)

  • Albert F. Magnusen

    (Cincinnati Children’s Hospital Medical Center)

  • Wujuan Zhang

    (Laboratory of Mass Spectroscopy, Cincinnati Children’s Hospital Medical Center)

  • Benjamin Liou

    (Cincinnati Children’s Hospital Medical Center)

  • Jörg Köhl

    (Cincinnati Children’s Hospital Medical Center
    Institute for Systemic Inflammation Research, University of Lübeck)

  • Gregory A. Grabowski

    (Cincinnati Children’s Hospital Medical Center)

Abstract

Complement-activating glycosylceramide-specific autoantibodies drive a self-propagating cycle of glycosylceramide accumulation and inflammation in Gaucher disease.

Suggested Citation

  • Manoj K. Pandey & Thomas A. Burrow & Reena Rani & Lisa J. Martin & David Witte & Kenneth D. Setchell & Mary A. Mckay & Albert F. Magnusen & Wujuan Zhang & Benjamin Liou & Jörg Köhl & Gregory A. Grabow, 2017. "Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease," Nature, Nature, vol. 543(7643), pages 108-112, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7643:d:10.1038_nature21368
    DOI: 10.1038/nature21368
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