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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

Author

Listed:
  • Kristen M. Turner

    (Ludwig Institute for Cancer Research, University of California at San Diego)

  • Viraj Deshpande

    (University of California at San Diego)

  • Doruk Beyter

    (University of California at San Diego)

  • Tomoyuki Koga

    (Ludwig Institute for Cancer Research, University of California at San Diego)

  • Jessica Rusert

    (Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute)

  • Catherine Lee

    (Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute)

  • Bin Li

    (Ludwig Institute for Cancer Research, University of California at San Diego)

  • Karen Arden

    (Ludwig Institute for Cancer Research, University of California at San Diego)

  • Bing Ren

    (Ludwig Institute for Cancer Research, University of California at San Diego)

  • David A. Nathanson

    (David Geffen UCLA School of Medicine)

  • Harley I. Kornblum

    (David Geffen UCLA School of Medicine
    David Geffen UCLA School of Medicine)

  • Michael D. Taylor

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children)

  • Sharmeela Kaushal

    (Moores Cancer Center, University of California at San Diego)

  • Webster K. Cavenee

    (Ludwig Institute for Cancer Research, University of California at San Diego)

  • Robert Wechsler-Reya

    (Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute)

  • Frank B. Furnari

    (Ludwig Institute for Cancer Research, University of California at San Diego)

  • Scott R. Vandenberg

    (University of California San Francisco)

  • P. Nagesh Rao

    (David Geffen UCLA School of Medicine)

  • Geoffrey M. Wahl

    (Gene Expression Laboratory, Salk Institute for Biological Studies)

  • Vineet Bafna

    (University of California at San Diego)

  • Paul S. Mischel

    (Ludwig Institute for Cancer Research, University of California at San Diego
    Moores Cancer Center, University of California at San Diego
    University of California at San Diego)

Abstract

Circular extrachromosomal DNA is found in nearly half of human cancers of a wide variety of histologic types, increasing the copy number of driver oncogenes and intratumoral heterogeneity more effectively than chromosomal amplification and contributing to tumor evolution.

Suggested Citation

  • Kristen M. Turner & Viraj Deshpande & Doruk Beyter & Tomoyuki Koga & Jessica Rusert & Catherine Lee & Bin Li & Karen Arden & Bing Ren & David A. Nathanson & Harley I. Kornblum & Michael D. Taylor & Sh, 2017. "Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity," Nature, Nature, vol. 543(7643), pages 122-125, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7643:d:10.1038_nature21356
    DOI: 10.1038/nature21356
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    Cited by:

    1. Xue-Ke Zhao & Pengwei Xing & Xin Song & Miao Zhao & Linxuan Zhao & Yonglong Dang & Ling-Ling Lei & Rui-Hua Xu & Wen-Li Han & Pan-Pan Wang & Miao-Miao Yang & Jing-Feng Hu & Kan Zhong & Fu-You Zhou & Xu, 2021. "Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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