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Metabolic gatekeeper function of B-lymphoid transcription factors

Author

Listed:
  • Lai N. Chan

    (Beckman Research Institute and City of Hope National Medical Center
    City of Hope Comprehensive Cancer Center)

  • Zhengshan Chen

    (Beckman Research Institute and City of Hope National Medical Center
    City of Hope Comprehensive Cancer Center)

  • Daniel Braas

    (UCLA Metabolomics Center and Crump Institute for Molecular Imaging, University of California Los Angeles)

  • Jae-Woong Lee

    (Beckman Research Institute and City of Hope National Medical Center
    City of Hope Comprehensive Cancer Center)

  • Gang Xiao

    (Beckman Research Institute and City of Hope National Medical Center
    City of Hope Comprehensive Cancer Center)

  • Huimin Geng

    (University of California San Francisco)

  • Kadriye Nehir Cosgun

    (Beckman Research Institute and City of Hope National Medical Center
    City of Hope Comprehensive Cancer Center)

  • Christian Hurtz

    (University of California San Francisco)

  • Seyedmehdi Shojaee

    (University of California San Francisco)

  • Valeria Cazzaniga

    (University of California San Francisco)

  • Hilde Schjerven

    (University of California San Francisco)

  • Thomas Ernst

    (Hämatologie/Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena)

  • Andreas Hochhaus

    (Hämatologie/Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena)

  • Steven M. Kornblau

    (The University of Texas M.D. Anderson Cancer Center)

  • Marina Konopleva

    (The University of Texas M.D. Anderson Cancer Center)

  • Miles A. Pufall

    (University of Iowa)

  • Giovanni Cazzaniga

    (Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale S. Gerardo)

  • Grace J. Liu

    (Australian Centre for Blood Diseases, Monash University)

  • Thomas A. Milne

    (MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford)

  • H. Phillip Koeffler

    (Cancer Science Institute of Singapore, National University of Singapore
    Cedars-Sinai Medical Center, University of California School of Medicine)

  • Theodora S. Ross

    (University of Texas Southwestern Medical Center)

  • Isidro Sánchez-García

    (Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca and Institute of Biomedical Research of Salamanca (IBSAL))

  • Arndt Borkhardt

    (Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University)

  • Keith R. Yamamoto

    (University of California San Francisco)

  • Ross A. Dickins

    (Australian Centre for Blood Diseases, Monash University)

  • Thomas G. Graeber

    (UCLA Metabolomics Center and Crump Institute for Molecular Imaging, University of California Los Angeles)

  • Markus Müschen

    (Beckman Research Institute and City of Hope National Medical Center
    City of Hope Comprehensive Cancer Center)

Abstract

The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensitizing acute lymphoblastic leukaemia B cells to glucocorticoid therapy.

Suggested Citation

  • Lai N. Chan & Zhengshan Chen & Daniel Braas & Jae-Woong Lee & Gang Xiao & Huimin Geng & Kadriye Nehir Cosgun & Christian Hurtz & Seyedmehdi Shojaee & Valeria Cazzaniga & Hilde Schjerven & Thomas Ernst, 2017. "Metabolic gatekeeper function of B-lymphoid transcription factors," Nature, Nature, vol. 542(7642), pages 479-483, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7642:d:10.1038_nature21076
    DOI: 10.1038/nature21076
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    Citations

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    Cited by:

    1. Jolanda Sarno & Pablo Domizi & Yuxuan Liu & Milton Merchant & Christina Bligaard Pedersen & Dorra Jedoui & Astraea Jager & Garry P. Nolan & Giuseppe Gaipa & Sean C. Bendall & Felice-Alessio Bava & Kar, 2023. "Dasatinib overcomes glucocorticoid resistance in B-cell acute lymphoblastic leukemia," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Robin D. Lee & Sarah A. Munro & Todd P. Knutson & Rebecca S. LaRue & Lynn M. Heltemes-Harris & Michael A. Farrar, 2021. "Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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