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Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

Author

Listed:
  • Benjamin Mordmüller

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Güzin Surat

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Heimo Lagler

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
    Medical University of Vienna)

  • Sumana Chakravarty

    (Sanaria Inc.)

  • Andrew S. Ishizuka

    (Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH))

  • Albert Lalremruata

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Markus Gmeiner

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Joseph J. Campo

    (Antigen Discovery Inc.)

  • Meral Esen

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Adam J. Ruben

    (Sanaria Inc.)

  • Jana Held

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Carlos Lamsfus Calle

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Juliana B. Mengue

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Tamirat Gebru

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Javier Ibáñez

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Mihály Sulyok

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

  • Eric R. James

    (Sanaria Inc.)

  • Peter F. Billingsley

    (Sanaria Inc.)

  • KC Natasha

    (Sanaria Inc.
    Protein Potential, LLC)

  • Anita Manoj

    (Sanaria Inc.)

  • Tooba Murshedkar

    (Sanaria Inc.)

  • Anusha Gunasekera

    (Sanaria Inc.)

  • Abraham G. Eappen

    (Sanaria Inc.)

  • Tao Li

    (Sanaria Inc.)

  • Richard E. Stafford

    (Sanaria Inc.
    Protein Potential, LLC)

  • Minglin Li

    (Sanaria Inc.
    Protein Potential, LLC)

  • Phil L. Felgner

    (University of California Irvine)

  • Robert A. Seder

    (Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH))

  • Thomas L. Richie

    (Sanaria Inc.)

  • B. Kim Lee Sim

    (Sanaria Inc.
    Protein Potential, LLC)

  • Stephen L. Hoffman

    (Sanaria Inc.)

  • Peter G. Kremsner

    (Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen)

Abstract

Immunization with Plasmodium falciparum sporozoites under chemoprophylaxis can protect against controlled human malaria infection with the same strain for at least 10 weeks, and protection correlates with polyfunctional T-cell memory.

Suggested Citation

  • Benjamin Mordmüller & Güzin Surat & Heimo Lagler & Sumana Chakravarty & Andrew S. Ishizuka & Albert Lalremruata & Markus Gmeiner & Joseph J. Campo & Meral Esen & Adam J. Ruben & Jana Held & Carlos Lam, 2017. "Sterile protection against human malaria by chemoattenuated PfSPZ vaccine," Nature, Nature, vol. 542(7642), pages 445-449, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7642:d:10.1038_nature21060
    DOI: 10.1038/nature21060
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    Citations

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    Cited by:

    1. Hardik Patel & Nana K. Minkah & Sudhir Kumar & Gigliola Zanghi & Antonino Schepis & Debashree Goswami & Janna Armstrong & Biley A. Abatiyow & Will Betz & Laura Reynolds & Nelly Camargo & Amina A. Shei, 2024. "Malaria blood stage infection suppresses liver stage infection via host-induced interferons but not hepcidin," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Joana C. Silva & Ankit Dwivedi & Kara A. Moser & Mahamadou S. Sissoko & Judith E. Epstein & Sara A. Healy & Kirsten E. Lyke & Benjamin Mordmüller & Peter G. Kremsner & Patrick E. Duffy & Tooba Murshed, 2022. "Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Raquel Furtado & Mahinder Paul & Jinghang Zhang & Joowhan Sung & Paul Karell & Ryung S. Kim & Sophie Caillat-Zucman & Li Liang & Philip Felgner & Andy Bauleni & Syze Gama & Andrea Buchwald & Terrie Ta, 2023. "Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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