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EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice

Author

Listed:
  • Abul Arif

    (Lerner Research Institute, Cleveland Clinic)

  • Fulvia Terenzi

    (Lerner Research Institute, Cleveland Clinic)

  • Alka A. Potdar

    (F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center)

  • Jie Jia

    (Lerner Research Institute, Cleveland Clinic)

  • Jessica Sacks

    (Lerner Research Institute, Cleveland Clinic)

  • Arnab China

    (Lerner Research Institute, Cleveland Clinic)

  • Dalia Halawani

    (Lerner Research Institute, Cleveland Clinic)

  • Kommireddy Vasu

    (Lerner Research Institute, Cleveland Clinic)

  • Xiaoxia Li

    (Lerner Research Institute, Cleveland Clinic)

  • J. Mark Brown

    (Lerner Research Institute, Cleveland Clinic)

  • Jie Chen

    (University of Illinois)

  • Sara C. Kozma

    (Catalan Institute of Oncology, ICO, Bellvitge Biomedical Research Institute, IDIBELL
    Faculty of Medicine, University of Barcelona)

  • George Thomas

    (Catalan Institute of Oncology, ICO, Bellvitge Biomedical Research Institute, IDIBELL
    Faculty of Medicine, University of Barcelona
    College of Medicine, University of Cincinnati)

  • Paul L. Fox

    (Lerner Research Institute, Cleveland Clinic)

Abstract

Glutamyl-prolyl tRNA synthetase (EPRS) is a downstream effector of the mTORC1–S6K1 signalling axis and contributes to adiposity and ageing in mice.

Suggested Citation

  • Abul Arif & Fulvia Terenzi & Alka A. Potdar & Jie Jia & Jessica Sacks & Arnab China & Dalia Halawani & Kommireddy Vasu & Xiaoxia Li & J. Mark Brown & Jie Chen & Sara C. Kozma & George Thomas & Paul L., 2017. "EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice," Nature, Nature, vol. 542(7641), pages 357-361, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7641:d:10.1038_nature21380
    DOI: 10.1038/nature21380
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    Cited by:

    1. Debjit Khan & Iyappan Ramachandiran & Kommireddy Vasu & Arnab China & Krishnendu Khan & Fabio Cumbo & Dalia Halawani & Fulvia Terenzi & Isaac Zin & Briana Long & Gregory Costain & Susan Blaser & Amand, 2024. "Homozygous EPRS1 missense variant causing hypomyelinating leukodystrophy-15 alters variant-distal mRNA m6A site accessibility," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. Scisung Chung & Mi-Sun Kang & Dauren S. Alimbetov & Gil-Im Mun & Na-Oh Yunn & Yunjin Kim & Byung-Gyu Kim & Minwoo Wie & Eun A. Lee & Jae Sun Ra & Jung-Min Oh & Donghyun Lee & Keondo Lee & Jihan Kim & , 2022. "Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Eun-Young Lee & Su-Man Kim & Jung Hwan Hwang & Song Yee Jang & Shinhye Park & Sanghyeon Choi & Ga Seul Lee & Jungwon Hwang & Jeong Hee Moon & Paul L. Fox & Sunghoon Kim & Chul-Ho Lee & Myung Hee Kim, 2022. "Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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