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Structure of a spliceosome remodelled for exon ligation

Author

Listed:
  • Sebastian M. Fica

    (MRC Laboratory of Molecular Biology)

  • Chris Oubridge

    (MRC Laboratory of Molecular Biology)

  • Wojciech P. Galej

    (MRC Laboratory of Molecular Biology
    †Present address: EMBL Grenoble, 71 avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France.)

  • Max E. Wilkinson

    (MRC Laboratory of Molecular Biology)

  • Xiao-Chen Bai

    (MRC Laboratory of Molecular Biology)

  • Andrew J. Newman

    (MRC Laboratory of Molecular Biology)

  • Kiyoshi Nagai

    (MRC Laboratory of Molecular Biology)

Abstract

The cryo-electron microscopy structure of a yeast spliceosome stalled before mature RNA formation provides insight into the mechanism of exon ligation.

Suggested Citation

  • Sebastian M. Fica & Chris Oubridge & Wojciech P. Galej & Max E. Wilkinson & Xiao-Chen Bai & Andrew J. Newman & Kiyoshi Nagai, 2017. "Structure of a spliceosome remodelled for exon ligation," Nature, Nature, vol. 542(7641), pages 377-380, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7641:d:10.1038_nature21078
    DOI: 10.1038/nature21078
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    Cited by:

    1. Min-Han Lin & Madeline K. Jensen & Nathan D. Elrod & Kai-Lieh Huang & Kevin A. Welle & Eric J. Wagner & Liang Tong, 2022. "Inositol hexakisphosphate is required for Integrator function," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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