IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v542y2017i7641d10.1038_nature21077.html
   My bibliography  Save this article

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

Author

Listed:
  • Yu-Lu Cao

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • Shuxia Meng

    (California Institute of Technology)

  • Yang Chen

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • Jian-Xiong Feng

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • Dong-Dong Gu

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • Bing Yu

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • Yu-Jie Li

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • Jin-Yu Yang

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • Shuang Liao

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • David C. Chan

    (California Institute of Technology)

  • Song Gao

    (State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

Abstract

Crystal structures of engineered human MFN1 in different stages of GTP hydrolysis provide insights into the GTP-induced conformational changes that promote MFN1 dimerization to bring about mitochondrial fusion.

Suggested Citation

  • Yu-Lu Cao & Shuxia Meng & Yang Chen & Jian-Xiong Feng & Dong-Dong Gu & Bing Yu & Yu-Jie Li & Jin-Yu Yang & Shuang Liao & David C. Chan & Song Gao, 2017. "MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion," Nature, Nature, vol. 542(7641), pages 372-376, February.
  • Handle: RePEc:nat:nature:v:542:y:2017:i:7641:d:10.1038_nature21077
    DOI: 10.1038/nature21077
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature21077
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature21077?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lucas Gewehr & Benedikt Junglas & Ruven Jilly & Johannes Franz & Wenyu Eva Zhu & Tobias Weidner & Mischa Bonn & Carsten Sachse & Dirk Schneider, 2023. "SynDLP is a dynamin-like protein of Synechocystis sp. PCC 6803 with eukaryotic features," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Emmanouil Zacharioudakis & Bogos Agianian & Vasantha Kumar MV & Nikolaos Biris & Thomas P. Garner & Inna Rabinovich-Nikitin & Amanda T. Ouchida & Victoria Margulets & Lars Ulrik Nordstrøm & Joel S. Ri, 2022. "Modulating mitofusins to control mitochondrial function and signaling," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Shuaifeng Li & Shixun Han & Qi Zhang & Yibing Zhu & Haitao Zhang & Junli Wang & Yang Zhao & Jianhui Zhao & Lin Su & Li Li & Dawang Zhou & Cunqi Ye & Xin-Hua Feng & Tingbo Liang & Bin Zhao, 2022. "FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:542:y:2017:i:7641:d:10.1038_nature21077. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.