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Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Author

Listed:
  • Giannicola Genovese

    (The University of Texas MD Anderson Cancer Center)

  • Alessandro Carugo

    (The University of Texas MD Anderson Cancer Center
    Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    European Institute of Oncology
    †Present addresses: C4 Therapeutics, Cambridge, Massachusetts 02142, USA (T.P.H.); Institute for Health Transformation, The University of Texas System, Austin, Texas 78701, USA (L.C.))

  • James Tepper

    (The University of Texas MD Anderson Cancer Center)

  • Frederick Scott Robinson

    (The University of Texas MD Anderson Cancer Center
    Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Liren Li

    (The University of Texas MD Anderson Cancer Center
    Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, 510060, China)

  • Maria Svelto

    (The University of Texas MD Anderson Cancer Center
    Istituto di Patologia Generale, Universitá Cattolica del Sacro Cuore, Rome 00168, Italy)

  • Luigi Nezi

    (The University of Texas MD Anderson Cancer Center)

  • Denise Corti

    (The University of Texas MD Anderson Cancer Center)

  • Rosalba Minelli

    (The University of Texas MD Anderson Cancer Center)

  • Piergiorgio Pettazzoni

    (The University of Texas MD Anderson Cancer Center)

  • Tony Gutschner

    (The University of Texas MD Anderson Cancer Center)

  • Chia-Chin Wu

    (The University of Texas MD Anderson Cancer Center)

  • Sahil Seth

    (The University of Texas MD Anderson Cancer Center)

  • Kadir Caner Akdemir

    (The University of Texas MD Anderson Cancer Center)

  • Elisabetta Leo

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Samirkumar Amin

    (The University of Texas MD Anderson Cancer Center
    Graduate program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA)

  • Marco Dal Molin

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21287, USA)

  • Haoqiang Ying

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Lawrence N. Kwong

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Simona Colla

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Koichi Takahashi

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Papia Ghosh

    (Office of Technology Commercialization, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Virginia Giuliani

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Florian Muller

    (The University of Texas MD Anderson Cancer Center)

  • Prasenjit Dey

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Shan Jiang

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Jill Garvey

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Chang-Gong Liu

    (The University of Texas MD Anderson Cancer Center)

  • Jianhua Zhang

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Timothy P. Heffernan

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    †Present addresses: C4 Therapeutics, Cambridge, Massachusetts 02142, USA (T.P.H.); Institute for Health Transformation, The University of Texas System, Austin, Texas 78701, USA (L.C.))

  • Carlo Toniatti

    (ORBIT Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Jason B. Fleming

    (The University of Texas MD Anderson Cancer Center)

  • Michael G. Goggins

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21287, USA)

  • Laura D. Wood

    (The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21287, USA)

  • Alessandro Sgambato

    (Istituto di Patologia Generale, Universitá Cattolica del Sacro Cuore, Rome 00168, Italy)

  • Abbas Agaimy

    (Friedrich Alexander University Erlangen-Nuremberg, University Hospital)

  • Anirban Maitra

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Charles W. M. Roberts

    (St Jude Children’s Research Hospital, Memphis, Tennessee 77027, USA)

  • Huamin Wang

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Andrea Viale

    (The University of Texas MD Anderson Cancer Center)

  • Ronald A. DePinho

    (The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Giulio F. Draetta

    (The University of Texas MD Anderson Cancer Center
    Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA)

  • Lynda Chin

    (The University of Texas MD Anderson Cancer Center
    Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    †Present addresses: C4 Therapeutics, Cambridge, Massachusetts 02142, USA (T.P.H.); Institute for Health Transformation, The University of Texas System, Austin, Texas 78701, USA (L.C.))

Abstract

Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly aggressive Kras-independent pancreatic cancer cells to develop.

Suggested Citation

  • Giannicola Genovese & Alessandro Carugo & James Tepper & Frederick Scott Robinson & Liren Li & Maria Svelto & Luigi Nezi & Denise Corti & Rosalba Minelli & Piergiorgio Pettazzoni & Tony Gutschner & Ch, 2017. "Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer," Nature, Nature, vol. 542(7641), pages 362-366, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7641:d:10.1038_nature21064
    DOI: 10.1038/nature21064
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    Citations

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    Cited by:

    1. L. Paige Ferguson & Jovylyn Gatchalian & Matthew L. McDermott & Mari Nakamura & Kendall Chambers & Nirakar Rajbhandari & Nikki K. Lytle & Sara Brin Rosenthal & Michael Hamilton & Sonia Albini & Martin, 2023. "Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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