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Inflammation, metaflammation and immunometabolic disorders

Author

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  • Gökhan S. Hotamisligil

    (Harvard T.H. Chan School of Public Health, Broad Institute of Harvard and MIT)

Abstract

Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.

Suggested Citation

  • Gökhan S. Hotamisligil, 2017. "Inflammation, metaflammation and immunometabolic disorders," Nature, Nature, vol. 542(7640), pages 177-185, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7640:d:10.1038_nature21363
    DOI: 10.1038/nature21363
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    Cited by:

    1. Miao Yu & Lihua Wang & Shengkui Zhang & Hongman Feng & Jianhui Wu & Xiaoming Li & Juxiang Yuan, 2022. "Association between Neck Circumference and Subclinical Atherosclerosis among Chinese Steelworkers: A Cross-Sectional Survey," IJERPH, MDPI, vol. 19(11), pages 1-9, May.
    2. Rohanizah Abdul Rahim & Putri Ayu Jayusman & Norliza Muhammad & Norazlina Mohamed & Vuanghao Lim & Nor Hazwani Ahmad & Sharlina Mohamad & Zuratul Ain Abdul Hamid & Fairus Ahmad & Norfilza Mokhtar & Ah, 2021. "Potential Antioxidant and Anti-Inflammatory Effects of Spilanthes acmella and Its Health Beneficial Effects: A Review," IJERPH, MDPI, vol. 18(7), pages 1-15, March.

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