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Molecular mechanism for the regulation of yeast separase by securin

Author

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  • Shukun Luo

    (Columbia University)

  • Liang Tong

    (Columbia University)

Abstract

The crystal structure of yeast separase in complex with its inhibitor securin sheds light on the mechanism of inhibition, in which securin inhibits separase by inserting a short segment into the active site.

Suggested Citation

  • Shukun Luo & Liang Tong, 2017. "Molecular mechanism for the regulation of yeast separase by securin," Nature, Nature, vol. 542(7640), pages 255-259, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7640:d:10.1038_nature21061
    DOI: 10.1038/nature21061
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    Cited by:

    1. Christopher Thomas & Benjamin Wetherall & Mark D. Levasseur & Rebecca J. Harris & Scott T. Kerridge & Jonathan M. G. Higgins & Owen R. Davies & Suzanne Madgwick, 2021. "A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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