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Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Author

Listed:
  • Deepak A. Rao

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Michael F. Gurish

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Jennifer L. Marshall

    (Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital)

  • Kamil Slowikowski

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School
    Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute and Harvard University
    Partners Center for Personalized Genetic Medicine)

  • Chamith Y. Fonseka

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School
    Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute and Harvard University
    Bioinformatics and Integrative Genomics, Harvard University)

  • Yanyan Liu

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Laura T. Donlin

    (Arthritis and Tissue Degeneration Program, Hospital for Special Surgery
    David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery)

  • Lauren A. Henderson

    (Boston Children’s Hospital)

  • Kevin Wei

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Fumitaka Mizoguchi

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Nikola C. Teslovich

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School
    Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute and Harvard University)

  • Michael E. Weinblatt

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Elena M. Massarotti

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Jonathan S. Coblyn

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Simon M. Helfgott

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Yvonne C. Lee

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Derrick J. Todd

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Vivian P. Bykerk

    (Hospital for Special Surgery
    Weill Cornell Medical College, Cornell University)

  • Susan M. Goodman

    (Hospital for Special Surgery
    Weill Cornell Medical College, Cornell University)

  • Alessandra B. Pernis

    (David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
    Weill Cornell Medical College, Cornell University
    Autoimmunity and Inflammation Program, Hospital for Special Surgery)

  • Lionel B. Ivashkiv

    (Arthritis and Tissue Degeneration Program, Hospital for Special Surgery
    David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery)

  • Elizabeth W. Karlson

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

  • Peter A. Nigrovic

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
    Boston Children’s Hospital)

  • Andrew Filer

    (Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital)

  • Christopher D. Buckley

    (Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital)

  • James A. Lederer

    (Brigham and Women’s Hospital)

  • Soumya Raychaudhuri

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
    Brigham and Women’s Hospital and Harvard Medical School
    Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute and Harvard University
    Partners Center for Personalized Genetic Medicine)

  • Michael B. Brenner

    (Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School)

Abstract

The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues.

Suggested Citation

  • Deepak A. Rao & Michael F. Gurish & Jennifer L. Marshall & Kamil Slowikowski & Chamith Y. Fonseka & Yanyan Liu & Laura T. Donlin & Lauren A. Henderson & Kevin Wei & Fumitaka Mizoguchi & Nikola C. Tesl, 2017. "Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis," Nature, Nature, vol. 542(7639), pages 110-114, February.
    • Handle: RePEc:nat:nature:v:542:y:2017:i:7639:d:10.1038_nature20810
    DOI: 10.1038/nature20810
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    Citations

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    Cited by:

    1. Taehyeung Kim & Marta Martínez-Bonet & Qiang Wang & Nicolaj Hackert & Jeffrey A. Sparks & Yuriy Baglaenko & Byunghee Koh & Roxane Darbousset & Raquel Laza-Briviesca & Xiaoting Chen & Vitor R. C. Aguia, 2024. "Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Alexandra Argyriou & Marc H. Wadsworth & Adrian Lendvai & Stephen M. Christensen & Aase H. Hensvold & Christina Gerstner & Annika Vollenhoven & Kellie Kravarik & Aaron Winkler & Vivianne Malmström & K, 2022. "Single cell sequencing identifies clonally expanded synovial CD4+ TPH cells expressing GPR56 in rheumatoid arthritis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Kathryn Weinand & Saori Sakaue & Aparna Nathan & Anna Helena Jonsson & Fan Zhang & Gerald F. M. Watts & Majd Al Suqri & Zhu Zhu & Deepak A. Rao & Jennifer H. Anolik & Michael B. Brenner & Laura T. Don, 2024. "The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
    4. David G. Priest & Takeshi Ebihara & Janyerkye Tulyeu & Jonas N. Søndergaard & Shuhei Sakakibara & Fuminori Sugihara & Shunichiro Nakao & Yuki Togami & Jumpei Yoshimura & Hiroshi Ito & Shinya Onishi & , 2024. "Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    5. Takuya Harada & Yoshikane Kikushige & Toshihiro Miyamoto & Kazuko Uno & Hiroaki Niiro & Atsushi Kawakami & Tomohiro Koga & Koichi Akashi & Kazuyuki Yoshizaki, 2023. "Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Pai Wang & Xin Yang & Luyao Zhang & Sha Sha & Juan Huang & Jian Peng & Jianlei Gu & James Alexander Pearson & Youjia Hu & Hongyu Zhao & F. Susan Wong & Quan Wang & Li Wen, 2024. "Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    7. Kenneth F. Baker & David McDonald & Gillian Hulme & Rafiqul Hussain & Jonathan Coxhead & David Swan & Axel R. Schulz & Henrik E. Mei & Lucy MacDonald & Arthur G. Pratt & Andrew Filby & Amy E. Anderson, 2024. "Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    8. Kevin J. Kramer & Erin M. Wilfong & Kelsey Voss & Sierra M. Barone & Andrea R. Shiakolas & Nagarajan Raju & Caroline E. Roe & Naveenchandra Suryadevara & Lauren M. Walker & Steven C. Wall & Ariana Pau, 2022. "Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    9. Garrett Dunlap & Aaron Wagner & Nida Meednu & Ruoqiao Wang & Fan Zhang & Jabea Cyril Ekabe & Anna Helena Jonsson & Kevin Wei & Saori Sakaue & Aparna Nathan & Vivian P. Bykerk & Laura T. Donlin & Susan, 2024. "Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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