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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

Author

Listed:
  • Adrian Britschgi

    (Friedrich Miescher Institute for Biomedical Research)

  • Stephan Duss

    (Friedrich Miescher Institute for Biomedical Research)

  • Sungeun Kim

    (Genomics Institute of the Novartis Research Foundation)

  • Joana Pinto Couto

    (Friedrich Miescher Institute for Biomedical Research
    University of Basel, University Hospital Basel)

  • Heike Brinkhaus

    (Friedrich Miescher Institute for Biomedical Research)

  • Shany Koren

    (Friedrich Miescher Institute for Biomedical Research
    University of Basel, University Hospital Basel)

  • Duvini De Silva

    (Friedrich Miescher Institute for Biomedical Research
    University of Basel, University Hospital Basel)

  • Kirsten D. Mertz

    (Institute of Pathology Liestal, Cantonal Hospital Baselland)

  • Daniela Kaup

    (Institute of Pathology Liestal, Cantonal Hospital Baselland)

  • Zsuzsanna Varga

    (Institute of Surgical Pathology, University Hospital Zurich)

  • Hans Voshol

    (Novartis Institutes for Biomedical Research)

  • Alexandra Vissieres

    (Novartis Institutes for Biomedical Research)

  • Cedric Leroy

    (Friedrich Miescher Institute for Biomedical Research
    Novartis Institutes for Biomedical Research)

  • Tim Roloff

    (Friedrich Miescher Institute for Biomedical Research)

  • Michael B. Stadler

    (Friedrich Miescher Institute for Biomedical Research
    Swiss Institute of Bioinformatics)

  • Christina H. Scheel

    (Institute of Stem Cell Research, German Research Center for Environmental Health)

  • Loren J. Miraglia

    (Genomics Institute of the Novartis Research Foundation)

  • Anthony P. Orth

    (Genomics Institute of the Novartis Research Foundation)

  • Ghislain M. C. Bonamy

    (Genomics Institute of the Novartis Research Foundation)

  • Venkateshwar A. Reddy

    (Genomics Institute of the Novartis Research Foundation)

  • Mohamed Bentires-Alj

    (Friedrich Miescher Institute for Biomedical Research
    University of Basel, University Hospital Basel)

Abstract

Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby changing human breast cell fate.

Suggested Citation

  • Adrian Britschgi & Stephan Duss & Sungeun Kim & Joana Pinto Couto & Heike Brinkhaus & Shany Koren & Duvini De Silva & Kirsten D. Mertz & Daniela Kaup & Zsuzsanna Varga & Hans Voshol & Alexandra Vissie, 2017. "The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα," Nature, Nature, vol. 541(7638), pages 541-545, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7638:d:10.1038_nature20829
    DOI: 10.1038/nature20829
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    Citations

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    Cited by:

    1. Yael Aylon & Noa Furth & Giuseppe Mallel & Gilgi Friedlander & Nishanth Belugali Nataraj & Meng Dong & Ori Hassin & Rawan Zoabi & Benjamin Cohen & Vanessa Drendel & Tomer Meir Salame & Saptaparna Mukh, 2022. "Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Shenghong Ma & Tracy Tang & Gary Probst & Andrei Konradi & Chunyu Jin & Fulong Li & J. Silvio Gutkind & Xiang-Dong Fu & Kun-Liang Guan, 2022. "Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Joseph G. Kern & Andrew M. Tilston-Lunel & Anthony Federico & Boting Ning & Amy Mueller & Grace B. Peppler & Eleni Stampouloglou & Nan Cheng & Randy L. Johnson & Marc E. Lenburg & Jennifer E. Beane & , 2022. "Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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